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MetabolomicsA metabolomic study of adipose tissue in mice with a disruption of the circadian system

Adipose tissue functions in terms of energy homeostasis as a rheostat for blood triglyceride, regulating its concentration, in response to external stimuli. In addition it acts as a barometer to inform the central nervous system of energy levels which can vary dramatically between meals and accor...

2017-10-27 | MTBLS390 | MetaboLights
TranscriptomicsTranscription profiling of liver from wistar and kyoto rats exposed to orotic acid to investigate fatty liver disease
Although fatty liver disease is caused by a number of toxicological insults and the metabolic syndrome, the exact mechanisms by which many of these pathophysiological stimulii induce fatty liver are unknown. The rapid and profound steatosis caused by orotic acid, resulting from an impairment in the ...
ORGANISM(S): Rattus norvegicus 
2009-03-11 | E-BIID-1 | biostudies-arrayexpress
TranscriptomicsTemporal changes of gene expression in rat kidney and lung, and the effect of prior growth inhibition on these changes
Temporal changes of gene expression from 1-wk- to 5-wk-old rat in kidney and lung, and the effect of prior growth inhibition on these genetic changes. In mammals, body growth is rapid in early life but decelerates with age. Somatic growth deceleration is caused by a gradual decline in cell prolifera...
ORGANISM(S): Rattus norvegicus 
2010-09-16 | E-GEOD-16792 | biostudies-arrayexpress
TranscriptomicsSpatial and Temporal Regulation of Gene Expression in the Mammalian Growth Plate
To explore the mechanisms responsible for spatial and temporal regulation of the growth plate, we microdissected postnatal rat growth plates into their constituent zones and then used microarray analysis to characterize the changes in gene expression that occur as chondrocytes undergo spatially-asso...
ORGANISM(S): Rattus norvegicus 
2010-02-22 | E-GEOD-16981 | biostudies-arrayexpress
TranscriptomicsTemporal changes of gene expression in mouse heart, kidney and lung during juvenile growth
Temporal changes of gene expression from 1-wk- to 4-wk and 8-wk-old mouse in heart, kidney and lung. Mammalian somatic growth is rapid in early postnatal life but then slows and eventually ceases in multiple tissues. We hypothesized that there exists a postnatal gene expression program that is commo...
ORGANISM(S): Mus musculus 
2012-06-15 | E-GEOD-38754 | biostudies-arrayexpress
TranscriptomicsIndian Hedgehog Signaling in the Postnatal Growth Plate
In order to characterize mRNA expression in the growth plate, we microdissected postnatal rat growth plates into their constituent zones and used microarray analysis to assess the abundences of individual transcripts. Expression patterns of PTHrP and Ihh-related genes were confirmed using real-time ...
ORGANISM(S): Rattus norvegicus 
2010-12-01 | E-GEOD-23432 | biostudies-arrayexpress
MetabolomicsA metabolomic study of adipose tissue in mice with a disruption of the circadian system

Adipose tissue functions in terms of energy homeostasis as a rheostat for blood triglyceride, regulating its concentration, in response to external stimuli. In addition it acts as a barometer to inform the central nervous system of energy levels which can vary dramatically between meals and accor...

2017-10-27 | MTBLS380 | MetaboLights
MetabolomicsA metabolomic study of adipose tissue in mice with a disruption of the circadian system

Adipose tissue functions in terms of energy homeostasis as a rheostat for blood triglyceride, regulating its concentration, in response to external stimuli. In addition it acts as a barometer to inform the central nervous system of energy levels which can vary dramatically between meals and accor...

2017-10-27 | MTBLS382 | MetaboLights
TranscriptomicsEvidence that variation in adult body size among mammalian species is achieved by modulating the pace of a growth-regulating genetic program
Body size varies enormously among mammalian species. In small mammals, body growth is typically suppressed rapidly, within weeks, whereas in large mammals, growth is suppressed slowly, over years, allowing for a greater adult size. We recently reported evidence that body growth suppression in rodent...
ORGANISM(S): Ovis aries 
2014-05-19 | E-GEOD-48916 | biostudies-arrayexpress
MetabolomicsMetabolomics dataset of PPAR-pan treated rat liver (eicosanoid assay)

This article contains mass spectrometry (MS) data investigating small molecule changes as an effect of a triple peroxisome proliferator-activated receptor (PPAR-pan) agonist GW625019 in the liver as described in the manuscript “PPAR-pan Activation Induces Hepatic Oxidative Stress and Lipidomic Re...

2016-05-13 | MTBLS278 | MetaboLights
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