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ProteomicsA spiked human proteomic dataset from human osteogenic differentiated BMSCs and ASCs for use as a spectral library, for modelling pathways as well as protein mapping
This article describes a mass spectrometry data set generated from osteogenic differentiated bone marrow stromal cells (BMSCs) and adipose tissue derived stromal cells (ASCs) of a 24-year old healthy donor spiked with iRT peptides. Cells have been identified via FACS-Analysis positive for CD90 and C...
ORGANISM(S): Homo sapiens (Human) 
2019-10-22 | PXD015026 | Pride
Data-independent acquisition analysis Nanohplc-esi-ms/ms Osteogenic differentiated mesenchymal stem cells 
ProteomicsHuman tear fluid proteome dataset for usage as a spectral library and for protein modeling
This article provides a detailed dataset of human tear fluid proteins. Samples were fractionated by sodium dodecyl sulfate (SDS) gel electrophoresis resulting in 48 fractions that were spiked with an indexed retention time (iRT) peptide standard. These data are based on a data-dependent acquisition ...
ORGANISM(S): Homo sapiens (Human) 
2019-08-15 | PXD011075 | Pride
Dia Protein modeling Tear fluid Spectral library Dda Lc-ms/ms 
ProteomicsProteomic analysis of retinal tissue in an S100B autoimmune glaucoma model
Glaucoma is not only the second leading cause of blindness worldwide, but patient numbers will also increase significantly in the coming years due to aging societies. Glaucoma is a progressive optic neuropathy with changes at the optic nerve head, gradual retinal ganglion cell (RGC) death, and visua...
ORGANISM(S): Rattus norvegicus (Rat) 
2022-02-16 | PXD023995 | Pride
Autoimmune glaucoma Proteomics Ls-ms/ms Normal tension S100b 
ProteomicsRat retinae data for use as spectral library, for pathway remodelling as well as protein mapping
Spectral libraries generated by data-dependent acquisition (DDA) are a useful tool for the analysis of data created by data-independent acquisition (DIA) in mass spectrometry. The quality of DIA analysis is dependent on the quality of the spectral library. We used retinal rat tissue to create a spec...
ORGANISM(S): Rattus norvegicus (Rat) 
2021-06-08 | PXD021937 | Pride
Lc-msms Rat Retina proteome Data-independent acquisition Spectral library 
ProteomicsComparative intraindividual proteomic analysis of osteogenic differentiated adipose tissue-derived and bone marrow-derived mesenchymal stem cells reveals integrin expression profile as distinctive feature
The treatment of bone defects caused by infection, trauma or neoplasms remains a clinical challenge. Autologous bone transplantation is limited by availability, donor site morbidity and surgical risk factors. This has given rise to stromal/stem-cell based therapy. Bone marrow derived stromal cells (...
ORGANISM(S): Homo sapiens (Human) 
2021-06-09 | PXD015223 | Pride
Dia-based proteomics Bone defect Osteogenic differentiated human stem cells Integrin 
ProteomicsInvestigation of inter- and intra-day variability of tear fluid regarding flow rate, protein concentration as well as protein composition
Purpose: Determination of inter- and intra-day variations in tear flow rate, tear fluid protein concentration as well as protein composition regarding their impact for future biomarker studies.Methods: Tear fluid was collected non-invasively from 18 healthy subjects performing Schirmer tests at four...
ORGANISM(S): Homo sapiens (Human) 
2023-10-24 | PXD037811 | Pride
Mass spectrometry Tear fluid Schirmer test Tear flow rate  tear volume Protein concentration 
ProteomicsDon’t die like me: Which proteins are responsible for the selective neuronal vulnerability within the substantia nigra?
A hallmark of Parkinson’s disease is the specific degeneration of dopaminergic neurons in the substantia nigra pars compacta. Interestingly, not all of these neurons are equally affected. Studies revealed that neurons located more ventrally within the substantia nigra pars compacta have a higher pre...
ORGANISM(S): Homo sapiens (Human) 
2024-08-09 | PXD037696 | Pride
Neurons Mass spectrometry Proteomic Selective neuronal vulnerability Substantia nigra 
ProteomicsSpiked human substantia nigra proteome data set for use as a spectral library for protein modelling and protein mapping
This article describes a mass spectrometry data set generated from human substantia nigra tissue that was spiked with iRT peptides. The data set can be used as a spectral library for analysis of the human brain, especially human substantia nigra, for example, in the context of Parkinson’s disease. O...
ORGANISM(S): Homo sapiens (Human) 
2019-08-15 | PXD011076 | Pride
Substantia nigra Protein modelling Spectral library Dda 
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