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UnknownEZH2 inhibits autophagic cell death of aortic vascular smooth muscle cells to affect aortic dissection.
Not available
S-EPMC5833461 | biostudies-literature
TranscriptomicsInduction of 1C Aldoketoreductases and Other Drug Dose-dependent Genes Upon Acquisition of Anthracycline Resistance
Recent studies have suggested that elevated expression of aldoketoreductase (AKR) 1C1 or 1C2 in tumour cells is associated with increased resistance to DNA damaging agents such as cisplatin and doxorubicin. However, it has not been shown whether selection of tumour cells for resistance to DNA-damag...
ORGANISM(S): Homo sapiens 
2008-07-16 | E-GEOD-12115 | biostudies-arrayexpress
ProteomicsSpatiotemporally direct capturing global substrates of post-translational modifying enzymes in living cells
Methods for direct capturing global substrates of protein-modifying enzymes in living cells are with many challenges, and yet largely unexplored. Here, we report a strategy to directly capture substrates of protein-modifying enzymes via PTM-acceptor residue crosslinking in living cells, enabling glo...
ORGANISM(S): Escherichia Coli 
2023-02-22 | PXD040318 |
ProteomicsSpatiotemporal and global profiling of DNA-protein interactions enables discovery of low-affinity transcription factors
Precise dissection of DNA-protein interactions is essential for elucidating recognition basis, dynamics, and gene regulation mechanism. However, global profiling of weak and dynamic DNA-protein interactions remains a long-standing challenge. Here, we establish light-induced lysine (K) enabled crossl...
ORGANISM(S): Homo Sapiens 
2023-01-03 | PXD039229 |
UnknownA Synthetic Disaccharide Derivative of Diphyllin, TAARD, Activates Human Natural Killer Cells to Secrete Interferon-Gamma via Toll-Like Receptor-Mediated NF-κB and STAT3 Signaling Pathways.
Not available
S-EPMC6058043 | biostudies-literature
TranscriptomicsGlobal gene expression analysis of embryos with spina bifida after maternal exposure to retinoic acid
Background The vitamin A derivative, retinoic acid (RA), is a potent teratogenic agent that induces a variety of congenital abnormalities including neural tube defects. The embryopathology of RA has been extensively investigated and retinol receptors play important roles during organogenesis, develo...
ORGANISM(S): Mus musculus 
2011-05-10 | E-GEOD-28834 | biostudies-arrayexpress
TranscriptomicsExpression data from AR3 transgenic and wild-type mouse prostates
We have established AR3 transgenic mouse models with targeted expression of AR3 in the prostate using the ARR2PB promoter. We have carried out gene expression profiling in AR3 transgenic prostate and wild-type prostate tissues respectively. We performed gene expression profiling in AR3 transgenic pr...
ORGANISM(S): Mus musculus 
2014-01-22 | E-GEOD-52092 | biostudies-arrayexpress
MetabolomicsMetabolic phenotyping of urine from a dementia research cohort
To better understand the molecular mechanisms underpinning physiological variation in human populations, metabolic phenotyping approaches are increasingly being applied to studies involving hundreds and thousands of biofluid samples. Hyphenated ultra-performance liquid chromatography-mass spectromet...
2022-03-01 | MTBLS719 | MetaboLights
UnknownDistinct patterns of somatic genome alterations in lung adenocarcinomas and squamous cell carcinomas.
Not available
S-EPMC4884143 | biostudies-literature
UnknownAssociation between alcohol and cardiovascular disease: Mendelian randomisation analysis based on individual participant data.
Not available
S-EPMC4091648 | biostudies-literature
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