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UnknownWhole-genome sequences of DA and F344 rats with different susceptibilities to arthritis, autoimmunity, inflammation and cancer.
Not available
S-EPMC3730908 | biostudies-literature
ProteomicsProteomic analysis revealed the important role of vimentin in human cervical carcinoma HeLa cells treated with gambogic acid
Gambogic acid (GA) is an anti-cancer agent in phase Ⅱb clinical trial in China. In HeLa cells, GA inhibited cell proliferation, induced cell cycle arrest at G2/M phase and apoptosis, as showed by results of MTT assay and flow cytometric analysis. Possible target-related proteins of GA were searched ...
ORGANISM(S): Homo sapiens (Human) 
2018-10-24 | PXD002975 | Pride
Anti-cancer Proteomics Gambogic acid Vimentin 
GenomicsIn vivo targeting of de novo DNA methylation by histone modifications in yeast and mouse (Bisulfite-Seq)
Methylation of cytosines (5meC) is a widespread heritable DNA modification. During mammalian development, two global demethylation events are followed by waves of de novo DNA methylation. In vivo mechanisms of DNA methylation establishment are largely uncharacterized. Here we use Saccharomyces cerev...
ORGANISM(S): Saccharomyces cerevisiae 
2015-04-02 | E-GEOD-66905 | biostudies-arrayexpress
MetabolomicsThe Kalanchoe genome provides insights into convergent evolution and building blocks of crassulacean acid metabolism
Crassulacean acid metabolism (CAM) is a water-use efficient adaptation of photosynthesis that has evolved independently many times in diverse lineages of flowering plants. We hypothesize that convergent evolution of protein sequence and temporal gene expression underpins the independent emergences o...
2018-01-09 | MTBLS519 | MetaboLights
ProteomicsFilter-aided expansion proteomics
Hydrogel-based tissue expansion combined with mass spectrometry (MS) offers an emerging spatial proteomics approach. Here, we present a filter-aided expansion proteomics (FAXP) strategy for spatial proteomics analysis of archived formalin-fixed paraffin-embedded (FFPE) specimens. Compared to our pre...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2024-10-01 | PXD041412 | Pride
Mass spectrometry Tissue expansion Ffpe Spatial proteomics Data-independent acquisition Colorectal cancer 
TranscriptomicsTranscription profiling of four strains of rat treated with tacrine
Comparison of tacrine 4 drug-treated individuals vs. 4 vehicle-treated, pooled individuals composed of 2 forward-labeled (Cy5: drug-treated individual, Cy3: vehicle-treated pool) and 2 reverse-labeled (Cy5: vehicle-treated pool, Cy3: drug-treated individual) slides. These comparisons were done acros...
ORGANISM(S): Rattus norvegicus 
2006-08-14 | E-TABM-129 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of gentamicin susceptible and resistant strains of rat treated with gentamicin
Comparison of Gentamicin 4 drug-treated individuals vs. 4 vehicle-treated, pooled individuals composed of 2 forward-labeled (Cy5: drug-treated individual, Cy3: vehicle-treated pool) and 2 reverse-labeled (Cy5: vehicle-treated pool, Cy3: drug-treated individual) slides. These comparisons were done a...
ORGANISM(S): Rattus norvegicus 
2006-04-01 | E-MEXP-544 | biostudies-arrayexpress
MetabolomicsMyeloid PFKFB3-mediated glycolysis promotes kidney fibrosis
Excessive renal fibrosis is a common pathology in progressive chronic kidney diseases. Inflammatory injury and aberrant repair processes contribute to the development of kidney fibrosis. Myeloid cells, particularly monocytes/macrophages, play a crucial role in kidney fibrosis by releasing their proi...
2024-03-12 | MTBLS8278 | MetaboLights
UnknownComprehensive profiling of alternative splicing landscape during cold acclimation in tea plant.
Not available
S-EPMC6971990 | biostudies-literature
TranscriptomicsInduction of 1C Aldoketoreductases and Other Drug Dose-dependent Genes Upon Acquisition of Anthracycline Resistance
Recent studies have suggested that elevated expression of aldoketoreductase (AKR) 1C1 or 1C2 in tumour cells is associated with increased resistance to DNA damaging agents such as cisplatin and doxorubicin. However, it has not been shown whether selection of tumour cells for resistance to DNA-damag...
ORGANISM(S): Homo sapiens 
2008-07-16 | E-GEOD-12115 | biostudies-arrayexpress
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