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MetabolomicsA new perspective on semen quality of aged male: The characteristics of metabolomics and proteomics

BACKGROUND: Semen quality is negatively correlated with male age and is mainly quantified by a routine semen analysis, which is descriptive and inconclusive. Sperm proteins or semen metabolites are used as the intermediate or end-products, reflecting changes in semen quality, an...

2024-01-16 | MTBLS5289 | MetaboLights
UnknownStevioside reduces inflammation in periodontitis by changing the oral bacterial composition and inhibiting P. gingivalis in mice.
Not available
S-EPMC10416424 | biostudies-literature
ProteomicsYi-xin-shu Capsule Ameliorates Cardiac Hypertrophy by Regulating RB/HDAC1/GATA4 Signaling Pathway in Abdominal Aorta Coarctation-Induced Rat Model
Background: Cardiac hypertrophy (CH) is the main pathological basis of malignant cadiovascular diseases such as chronic heart failure (CHF). Mitigating and preventing CH is the key strategy for the treatment of ventricular remodeling in CHF. Yi-Xin-Shu capsule (YXS) is highly applied in clinical tre...
ORGANISM(S): Rattus Rattus 
2021-05-26 | PXD026267 |
UnknownEffects of Bu Shen Yi Sui Capsule on Th17/Treg cytokines in C57BL/6 mice with experimental autoimmune encephalomyelitis.
Not available
S-EPMC4369831 | biostudies-literature
UnknownGelidocalamusalbozonatus (Poaceae, Bambusoideae), a new species from the southeast of Chongqing, China, and analysis of the morphological diversity in the core group of Gelidocalamus.
Not available
S-EPMC10693675 | biostudies-literature
UnknownForensic Features and Population Genetic Structure of Dong, Yi, Han, and Chuanqing Human Populations in Southwest China Inferred From Insertion/Deletion Markers.
Not available
S-EPMC7205039 | biostudies-literature
UnknownJian-Ti-Kang-Yi decoction alleviates poly(I:C)-induced pneumonia by inhibiting inflammatory response, reducing oxidative stress, and modulating host metabolism.
Not available
S-EPMC9486163 | biostudies-literature
UnknownComprehensive mutation screening for 10 genes in Chinese patients suffering very early onset inflammatory bowel disease.
Not available
S-EPMC4917618 | biostudies-literature
ProteomicsUSP36 stabilizes nucleolar Snail1 to promote ribosome biogenesis and cancer cell survival upon ribotoxic stress
Tumor growth requires elevated ribosome biogenesis. Targeting ribosomes is an important strategy for cancer therapy. The ribosome inhibitor, homoharringtonine (HHT), is used for the clinical treatment of leukemia, yet it is ineffective for the treatment of solid tumors, the reasons for which remain ...
ORGANISM(S): Homo sapiens (Human) 
2023-09-26 | PXD045622 | Pride
Usp36  snail1  ribosome biogenesis  ribotoxic stress 
ProteomicsUSP7 represses lineage differentiation genes in mouse embryonic stem cells by both catalytic and non-catalytic activity
USP7, a ubiquitin-specific peptidase (USP), plays an important role in many cellular processes through its catalytic deubiquitination of various substrates. However, its nuclear function to shape the transcriptional network in mouse embryonic stem cells (mESCs) remains poorly understood. Here, we re...
ORGANISM(S): Mus musculus (Mouse) 
2023-07-20 | PXD039633 | Pride
Pluripotent stem cells  usp7  polycomb  epigenetic regulation 
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