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ProteomicsIdentification of mitochondrial dysfunction in rheumatoid arthritis patients
Immune cells are majorly dysregulated in rheumatoid arthritis patients and are a major cause of pathogenesis and progression of this autoimmune condition. As mitochondria are master regulators of metabolism of all cells present in human body, it is of prime importance to study mitochondrial homeosta...
ORGANISM(S): Homo sapiens (Human) 
2020-06-22 | PXD011934 | Pride
Proteins Rheumatoid arthritis Mitochondrial dysfunction Pbmcs 
TranscriptomicsGenome-wide analysis of early transcriptional events induced by cytokine IL-4 in human cord blood CD4+ T cells
The aim of this dataset was to study in detail the transcription kinetics initiated by cytokine IL-4 in early differentiation of Th2 cells. Total RNA obtained from activated and IL-4 & anti-IL-12 treated cord blood CD4+ T cells, 0.5, 1, 2, 4, 6, 12, 24, 48, and 72 hours after initiation of the cultu...
ORGANISM(S): Homo sapiens 
2010-06-25 | E-GEOD-17974 | biostudies-arrayexpress
TranscriptomicsProviral integration site for Moloney murine leukemia virus (PIM) kinases promote human T helper 1 cell differentiation
The aim of the dataset was to study on genome-wide level the effect of PIM kinase (PIM1+PIM2+PIM3) knockdown in gene expression on early differentiation of human cord blood derived CD4+ T cells cultured under Th1 (Act+IL12) polarizing conditions. Total RNA from PIM1+PIM2+PIM3 siRNA treated cord bloo...
ORGANISM(S): Homo sapiens 
2012-12-05 | E-GEOD-40542 | biostudies-arrayexpress
GenomicsGenome-wide detection of STAT6 binding sites in IL-4 treated naive human CD4+ T cells
STAT6 is a major transcription factor driving the polarization of Th2 cells in response to IL-4. STAT6 is phosphorylated by Jak1 and Jak3 kinases at the IL-4 receptor, after which phosphorylated STAT6 forms a homodimer and translocates into the nucleus. There STAT6 binds to specific DNA sequences, r...
ORGANISM(S): Homo sapiens 
2010-06-25 | E-GEOD-17850 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of human Th17 cell differentiation
The study aims at identifying transcriptional changes induced by in vitro polarization of human cord blood CD4+ cells towards Th17 subtype with combination of IL6, IL1b and TGFb by using timeseries data. In this study, we identified gene expression changes characterizing early stages of human Th17 c...
ORGANISM(S): Homo sapiens 
2012-05-03 | E-GEOD-35103 | biostudies-arrayexpress
TranscriptomicsGenome-wide analysis of STAT6 target genes in IL-4 treated human cord blood CD4+ cells
STAT6 is a major transcription factor driving the polarization of Th2 cells in response to cytokine IL-4. Here we have analyzed on a genome wide level the STAT6 mediated gene expression after IL-4 induction in naive human CD4+ T cells. RNAi mediated STAT6 knockdown was used to reveal the genes speci...
ORGANISM(S): Homo sapiens 
2010-07-29 | E-GEOD-17851 | biostudies-arrayexpress
TranscriptomicsStat6 mediated regulation of transcription to initiate Th2 program in human T cells
This SuperSeries is composed of the following subset Series: GSE17850: Genome-wide detection of STAT6 binding sites in IL-4 treated naive human CD4+ T cells GSE17851: Genome-wide analysis of STAT6 target genes in IL-4 treated human cord blood CD4+ cells GSE17974: Genome-wide analysis of early transc...
ORGANISM(S): Homo sapiens 
2010-06-24 | E-GEOD-18017 | biostudies-arrayexpress
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