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ModelsSen2020 - Metabolic alteration in PBMCs associated with type 1 diabetes
Genome-Scale draft model for Human Peripheral Blood Mononuclear Cells (PBMCs). A GEM for PBMCs was developed by applying the INIT algorithm on Human Metabolic Reconstruction (HMR 2.0) as a template model. GEMs were contextualised/ constrained for different conditions using expression datasets. The g...
2020-03-11 | MODEL1905270001 | BioModels
ProteomicsGoat Peripheral Blood Mononuclear Cells (PBMCs) responses to infection vary with Peste des Petits Ruminants Virus virulence
Peste des Petits Ruminants (PPR) is a highly infectious disease caused by a virus of the genus Morbillivirus (PPRV), infecting mainly sheep and goat. Susceptibility of host can vary widely with host breed and virus strain. The mechanisms underlying this variability are not well understood. Here, we ...
ORGANISM(S): Peste des petits ruminants virus Capra hircus (Goat) 
2021-11-03 | PXD024890 | Pride
Pbmc Virulence Immune response Proteomics morbillivirus Peste des petits ruminants virus Goat 
GenomicsGenome-wide profiling of target genes for the systemic lupus erythematosus-associated transcription factors IRF5 and STAT4
IRF5 and STAT4 are strongly associated with human systemic lupus erythematosus (SLE). By performing chromatin immunoprecipitation-sequencing (ChIP-Seq) in human peripheral blood mononuclear cells (PBMCs), we identified more than 7000 target genes for IRF5 and STAT4 in stimulated PBMCs. Contrarily, w...
ORGANISM(S): Homo sapiens 
2012-06-08 | E-GEOD-38567 | biostudies-arrayexpress
GenomicsHomo sapiens strain:PBMCs
Homo sapiens strain:PBMCs Raw sequence reads
PRJNA899922 | ENA
ProteomicsGlycoproteomics and proteomics analysis of PBMCs from Colorectal Cancer patients
Non-invasive prognostic markers are needed to improve survival of colorectal cancer (CRC) patients. Towards this goal, we here apply integrative systems glycobiology approaches to tumour tissues and PBMCs from CRC patients and matching controls as well as a CRC patient-derived cell line. The untarge...
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD051907 | Pride
Proteomics Glycoproteomics Colorectal cancer Pbmcs 
GenomicsFAIRE-seq in PBMCs
FAIRE-seq in PBMCs
PRJNA415799 | ENA
TranscriptomicsAnalysis of microRNA proflie of peripheral blood mononuclear cells (PBMCs) in HIV-1 infected patients under different clinical status respect to hepatitis C virus (HCV) infection.
A total of 117 HIV-1 infected patients were analyzed. These individuals were categorized in three different groups according to their infectious status for HCV: A) HIV+/HCV+ group, (n=45) patients with HIV infection and active HCV-chronic infection naïve to any HCV treatment (positive PCR and positi...
ORGANISM(S): Homo sapiens 
2021-11-23 | E-MTAB-8274 | biostudies-arrayexpress
TranscriptomicsPPD stimulated PBMCs from tuberculosis patients, latent infectious individuals and healthy controls.
Comprehensively compare the transcriptional difference in PPD stimulated PBMCs from individuals with different tuberculosis infectious status: tuberculosis patients, latent infectious individuals and healthy controls using the microarray analysis. Two-condition experiment, PBMCs vs. PPD-PBMCs. 12 in...
ORGANISM(S): Homo sapiens 
2012-09-19 | E-GEOD-27984 | biostudies-arrayexpress
TranscriptomicsComparison of different hashing methods on human PBMCs and primary mice tissues
the aim 1 was to evaluate hashing (sample multiplexing) accuracy of TotalSeq-B antibodies and CellPlex (a multiplexing solution from 10x Genomics) on 2 pools of PBMCs from 3 different donors. Thus the genetic difference between donors was used as a ground truth for sample demultiplexing based on ant...
ORGANISM(S): Homo sapiens 
2022-02-12 | E-MTAB-11401 | biostudies-arrayexpress
TranscriptomicsAging-induced differential methylation in human PBMCs occurs with but often without change in expression of the associated gene (Expression)
Aging is a progressive process that results in the accumulation of intra- and extracellular alterations that in turn contribute to a reduction in health. Age-related changes in DNA methylation have been reported before and may be responsible for aging-induced changes in gene expression, although a c...
ORGANISM(S): Homo sapiens 
2014-05-09 | E-GEOD-49058 | biostudies-arrayexpress
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