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TranscriptomicsTime series ATAC-seq of Th1 differentiation: The effect of Progesterone on Th1 differentiation?
T-helper 1 responses are involved in the development of many autoimmune diseases such as Multiple sclerosis (MS). MS is a relapse remitting disease that eventually progresses to a progressive neurodegenerative disease. During pregnancy the relapse rate of MS is significantly reduced with peak reduct...
ORGANISM(S): Homo sapiens 
2021-09-09 | E-MTAB-10444 | biostudies-arrayexpress
TranscriptomicsTime series RNA-seq of Th1 differentiation: The effect of Progesterone on Th1 differentiation?
T-helper 1 responses are involved in the development of many autoimmune diseases such as Multiple sclerosis (MS). MS is a relapse remitting disease that eventually progresses to a progressive neurodegenerative disease. During pregnancy the relapse rate of MS is significantly reduced with peak reduct...
ORGANISM(S): Homo sapiens 
2021-09-09 | E-MTAB-10423 | biostudies-arrayexpress
TranscriptomicsEpigenome-wide DNA methylation profiling in cord blood CD4+ T cells from children treated prenatally with Lactobacillus reuteri and/or omega-3 fatty acids
In this study, we have examined the effect of combined prenatal Lactobacillus reuteri and omega-3 fatty acid supplementation on DNA methylation patterns in neonatal immune cells from children with a high propensity of developing allergies. We addressed this matter by assessing epigenome-wide DNA met...
ORGANISM(S): Homo sapiens 
2021-03-31 | E-MTAB-10341 | biostudies-arrayexpress
TranscriptomicsTime series RNA-seq of Naïve CD4 positive T-cells undergoing differentiation towards T-helper 1.
In eukaryotes, mRNA abundance is often a poor proxy for protein abundance. Despite this, the majority of methods used to dissect function in mammalian biology involve measurements of mRNA, with the assumption that changes observed at the mRNA level are reflected at the protein level. The inability t...
ORGANISM(S): Homo sapiens 
2021-09-09 | E-MTAB-7775 | biostudies-arrayexpress
TranscriptomicsIntegrated genomic and prospective clinical studies show the importance of modular pleiotropy for disease susceptibility, diagnosis and treatment (dataset 2)
Medical research focuses on disease-specific genes. By contrast, here we systematically examined the roles of shared genes for disease susceptibility and as therapeutic and diagnostic targets. Meta-analysis of all published disease-related genome-wide association studies (GWAS) showed that T helper ...
ORGANISM(S): Homo sapiens 
2014-03-07 | E-GEOD-44964 | biostudies-arrayexpress
TranscriptomicsIntegrated genomic and prospective clinical studies show the importance of modular pleiotropy for disease susceptibility, diagnosis and treatment (dataset 1)
Medical research focuses on disease-specific genes. By contrast, here we systematically examined the roles of shared genes for disease susceptibility and as therapeutic and diagnostic targets. Meta-analysis of all published disease-related genome-wide association studies (GWAS) showed that T helper ...
ORGANISM(S): Homo sapiens 
2014-03-07 | E-GEOD-44956 | biostudies-arrayexpress
TranscriptomicsEpigenome-wide DNA methylation profiling in CD4+ and CD8+ T cells from patients with multiple sclerosis and healthy controls followed during (1st, 2nd and 3rd trimester) and after pregnancy.
Patient with multiple sclerosis improves during pregnancy while temporarily worsening post-partum. The reasons behind the disease modulation during pregnancy remain unknown. In this study, we have investigated the effect of pregnancy on circulating CD4+ and CD8+ T cells from patients with multiple s...
ORGANISM(S): Homo sapiens 
2023-09-23 | E-MTAB-12250 | biostudies-arrayexpress
TranscriptomicsA module-based translational strategy shows a central role for S100A4 in allergy
The involvement of thousands of genes complicates the identification of clinically relevant candidate genes in common diseases. We hypothesized that genes co-regulated with a key gene in allergy, IL13, would form a module that could help to discover novel candidate genes. We identified a Th2 cell mo...
ORGANISM(S): Homo sapiens 
2014-02-05 | E-GEOD-46333 | biostudies-arrayexpress
TranscriptomicsA validated gene regulatory network and GWAS identifies early regulators of T-cell associated diseases (exon array)
In this work we present an analytical strategy to systematically identify early regulators by combining gene regulatory networks (GRN) with GWAS. We hypothesized that early regulators in T-cell associated diseases could be found by defining upstream transcription factors (TFs) in T-cell differentia...
ORGANISM(S): Homo sapiens 
2015-11-12 | E-GEOD-60677 | biostudies-arrayexpress
TranscriptomicsA validated gene regulatory network and GWAS identifies early regulators of T-cell associated diseases [MAF siRNA]
In this work we present an analytical strategy to systematically identify early regulators by combining gene regulatory networks (GRN) with GWAS. We hypothesized that early regulators in T-cell associated diseases could be found by defining upstream transcription factors (TFs) in T-cell differentia...
ORGANISM(S): Homo sapiens 
2015-11-12 | E-GEOD-61964 | biostudies-arrayexpress
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