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TranscriptomicsParkinson's disease-associated DJ-1 is required for the expression of GDNF receptor Ret in human neuroblastoma cells
DJ-1 is an atypical peroxiredoxin-like peroxidase that may act as a redox-dependent chaperone and a regulator of transcription. To explore DJ-1-mediated transcriptional control in Parkinsonâ??s disease (PD), we generated human neuroblastoma cells with inducible knock-down of DJ-1 expression. We then...
ORGANISM(S): Homo sapiens 
2010-04-28 | E-GEOD-17204 | biostudies-arrayexpress
TranscriptomicsA SUMOylated C-terminus fragment of glutamate transporter EAAT2 linked to inherited ALS mediates motor axon impairment
Downregulation of expression and activity levels of the astroglial glutamate transporter EAAT2 is thought to be implicated in motor neuron excitotoxicity in amyotrophic lateral sclerosis (ALS). We previously reported that EAAT2 is cleaved by caspase-3 at the cytosolic C-terminus domain, impairing th...
ORGANISM(S): Mus musculus 
2011-07-19 | E-GEOD-26070 | biostudies-arrayexpress
UnknownThe RNA-binding protein ILF3 binds to transposable element sequences in SINEUP lncRNAs.
Not available
S-EPMC6894054 | biostudies-literature
TranscriptomicsBlood transcriptomics of drug-naive sporadic Parkinson'?s disease patients
Parkinson's disease (PD) is a chronic progressive neurodegenerative disorder that is clinically defined in terms of motor symptoms. These are preceded by prodromal non-motor manifestations that prove the systemic nature of the disease. Identifying genes and pathways altered in living patients provid...
ORGANISM(S): Homo sapiens 
2015-10-29 | E-GEOD-72267 | biostudies-arrayexpress
TranscriptomicsForm deprivation modulates retinal neurogenesis in primate experimental myopia
Juvenile primates develop myopia when their visual experience is degraded by lid fusion. In response to the abnormal visual input, retinal neural networks cause an excessive growth of the postequatorial segment of the eye, but the mechanism underlying this axial elongation is unknown. By combining a...
ORGANISM(S): Macaca mulatta 
2010-07-01 | E-GEOD-3300 | biostudies-arrayexpress
UnknownExpression analysis of the long non-coding RNA antisense to Uchl1 (AS Uchl1) during dopaminergic cells' differentiation in vitro and in neurochemical models of Parkinson's disease.
Not available
S-EPMC4381646 | biostudies-literature
UnknownComposition of the GABA(A) receptors of retinal dopaminergic neurons.
Not available
S-EPMC6782470 | biostudies-literature
TranscriptomicsTranscription profiling of human neuroblastoma SH-SY5Y cells: 4h identifies molecular effectors of unconjugated bilirubin
The deposition of unconjugated bilirubin (UCB) in selected regions of the brain results in irreversible neuronal damage, or Bilirubin Encephalopathy (BE). Although UCB impairs a large number of cellular functions, the basic mechanisms of neurotoxicity have not yet been fully clarified. While cells c...
ORGANISM(S): Homo sapiens 
2009-12-02 | E-GEOD-16767 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human neuroblatoma SH-SY5Y cells: 24h identifies molecular effectors of unconjugated bilirubin
The deposition of unconjugated bilirubin (UCB) in selected regions of the brain results in irreversible neuronal damage, or Bilirubin Encephalopathy (BE). Although UCB impairs a large number of cellular functions, the basic mechanisms of neurotoxicity have not yet been fully clarified. While cells c...
ORGANISM(S): Homo sapiens 
2009-11-29 | E-GEOD-16656 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human human neuroblastoma SH-SY5Y cells: 1h identifies molecular effectors of unconjugated bilirubin
The deposition of unconjugated bilirubin (UCB) in selected regions of the brain results in irreversible neuronal damage, or Bilirubin Encephalopathy (BE). Although UCB impairs a large number of cellular functions, the basic mechanisms of neurotoxicity have not yet been fully clarified. While cells c...
ORGANISM(S): Homo sapiens 
2009-11-29 | E-GEOD-16766 | biostudies-arrayexpress
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