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MetabolomicsA microfluidic chip recapitulating the human neurovascular unit with a functional blood-brain barrier for modeling gut-brain interactions

The blood-brain barrier (BBB) is essential for central nervous system homeostasis, but most current in vitro models lack structural and functional fidelity. We developed a physiologically relevant human neurovascular unit microfluidic chip (hNVU-on-a-chip) incorporating brain microvascular endoth...

2025-10-28 | MTBLS13230 | MetaboLights
MetabolomicsMulti-level analysis of gut microbiome extracellular vesicles-host interaction reveals a connection to gut-brain axis signaling.

Microbiota-released extracellular vesicles (MEVs) have emerged as a key player in intercellular signaling. However, their involvement in the gut-brain axis has been poorly investigated. In this study, we aimed to investigate the cargo capacity of MEVs for bioactive metabolites and their interacti...

2025-08-12 | MTBLS8494 | MetaboLights
TranscriptomicsMicrobiota facilitates dietary heme-induced epithelial hyperproliferation and hyperplasia by breaking the mucus barrier
Colorectal cancer risk is associated with diets high in red meat. Heme, the pigment of red meat, induces cytotoxicity of colonic contents and elicits epithelial damage and compensatory hyperproliferation, leading to hyperplasia. Here we explore the possible causal role of the gut microbiota in heme-...
ORGANISM(S): Mus musculus 
2015-08-03 | E-GEOD-40670 | biostudies-arrayexpress
GenomicsOpioid-induced gut microbial disruption leads to gut barrier compromise and sustained systemic inflammation.
Morphine and its pharmacological derivatives are the most prescribed analgesics for moderate to severe pain management. However, chronic use of morphine reduces pathogen clearance and induces bacterial translocation across the gut barrier. The enteric microbiome has been shown to play a critical rol...
ORGANISM(S): Mus musculus domesticus 
2016-06-01 | E-MTAB-3722 | biostudies-arrayexpress
MetabolomicsDiallyl disulfide (DADS) ameliorates intestinal Candida albicans infection by modulating the gut microbiota and metabolites and providing intestinal protection in mice
Diallyl disulfide (DADS), a garlic extract also known as allicin, has been reported to have numerous biological activities, including anticancer, antifungal, and inflammation-inhibiting activities, among others. Although many studies have assessed whether DADS can treat Candida albicans infec...
2022-05-03 | MTBLS3750 | MetaboLights
MetabolomicsGut metabolomics of 6PPD-Q exposed mice with ABX treatment

Untargeted fecal metabolomics using UHPLC-MS/MS to analyze microbiota-dependent metabolic changes in C57BL/6 mice exposed to 6PPD-quinone (6PPD-Q) with/without antibiotic-mediated gut microbiota depletion. Key pathways include tryptophan and nicotinamide metabolism linked to intestinal barrier fu...

2026-09-15 | MTBLS14308 | MetaboLights
MetabolomicsOral administration of low-molecular-weight heparin ameliorates colitis by enhancing the gut mucus barrier via microbial tryptophan metabolites

Background and Purpose: Previous studies have reported that oral low molecular weight heparin (LMWH) ameliorated colitis by undefined mechanisms in ulcerative colitis (UC) patients. Our study explored the mechanisms of LMWH on colitis from the perspective of gut microbiota and its metabolites.

2025-10-12 | MTBLS5770 | MetaboLights
TranscriptomicsThe metabolic niche of a prominent sulfate-reducing human gut bacterium [3]
Sulfate-reducing bacteria (SRB) colonize the guts of ~50% of humans. We used genome-wide transposon mutagenesis and insertion-site sequencing (INSeq), RNA-Seq, plus mass spectrometry to characterize genetic and environmental factors that impact the niche of Desulfovibrio piger, the most common SRB i...
ORGANISM(S): Mus musculus 
2013-07-12 | E-GEOD-48808 | biostudies-arrayexpress
MetabolomicsLimosilactobacillus reuteri with indole-3-lactic acid-producing capacity protects against atherosclerosis by fortifying the gut-vascular barrier

Introduction: The gut microbiota and its metabolites are implicated in atherosclerosis, but the specific effector molecules and their pathophysiological significance remain unclear.

Objectives: This study aimed to identify key atheroprotective microbial metabolites and to elucidate the mech...

2026-01-31 | MTBLS13620 | MetaboLights
MetabolomicsPaeonol Ameliorates Ulcerative Colitis in Mice by Modulating the Gut Microbiota and its Metabolites

BACKGROUND: Ulcerative colitis (UC) is a chronic recurrent inflammatory disease of the gastrointestinal tract. Recent studies demonstrate that the phenolic tannin paeonol (Pae) attenuates UC in mouse models by downregulating inflammatory factors; however, molecular mechanisms lin...

2024-09-27 | MTBLS5204 | MetaboLights
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