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MetabolomicsRisk assessment with gut microbiome and metabolite markers in NAFLD development
A growing body of evidence suggests interplay between the gut microbiota and the pathogenesis of nonalcoholic fatty liver disease (NAFLD). However, the role of the gut microbiome in early detection of NAFLD is unclear. Prospective studies are necessary for identifying reliable, microbiome markers fo...
2022-07-11 | MTBLS2615 | MetaboLights
ProteomicsGut Microbial Ecosystem Multiomics in Inflammatory Bowel Disease
Using multiple omics approaches to explore the effect of the gut microbial ecosytem on inflammatory bowel disease
ORGANISM(S): Environmental Samples <bacteria> (ncbitaxon:48479) 
2019-07-02 | MSV000084050 | MassIVE
MetabolomicsGut microbiome dysbiosis drives metabolic dysfunction in Familial dysautonomia
Familial dysautonomia (FD) is a rare genetic neurologic disorder caused by impaired neuronal development and progressive degeneration of both the peripheral and central nervous systems. FD is monogenic, with >99.4% of patients sharing an identical point mutation in the elongator acetyltransferase co...
2022-12-06 | MTBLS5138 | MetaboLights
TranscriptomicsEffects of Gut Microbiota Manipulation by Antibiotics on Host Metabolism in Obese Humans: a Randomized Double-blind Placebo-controlled Trial
The gut microbiota has been implicated in obesity and cardiometabolic diseases, although evidence in humans is scarce. We investigated how gut microbiota manipulation by antibiotics (7-day administration of amoxicillin, vancomycin, or placebo) affects host metabolism in 57 obese, prediabetic men. Va...
ORGANISM(S): Homo sapiens 
2016-07-15 | E-GEOD-76003 | biostudies-arrayexpress
Transcriptomicshuman duodenum biopsy data
Using a systems biology approach, we discovered and dissected a three-way interaction between the immune system, the intestinal epithelium, and the microbiota. We found that mice lacking B lymphocytes, or lacking IgA, have low intestinal expression of lipid metabolism genes regulated by the transcri...
ORGANISM(S): Homo sapiens 
2011-11-15 | E-GEOD-23933 | biostudies-arrayexpress
TranscriptomicsCrosstalk between B lymphocytes, microbiota and the intestinal epithelium governs immunity versus metabolism in the gut
This SuperSeries is composed of the following subset Series: GSE23573: B-cell KO mice data GSE23933: human duodenum biopsy data GSE33884: The role of immunoglobulin A GSE33885: The role of transcription factor Gata4 Refer to individual Series
ORGANISM(S): Mus musculus 
2011-11-15 | E-GEOD-23934 | biostudies-arrayexpress
TranscriptomicsSingle-cell sequencing of developing human gut reveals transcriptional links to childhood Crohn’s disease
In this study, we performed single-cell transcriptional profiling of human embryonic and fetal gut samples obtained from 9 human embryos spanning ages 6-10 PCW and three regions (duo-jejunum, ileum and colon). Additionally, we profile mucosal biopsies from the terminal ileum of healthy children aged...
ORGANISM(S): Homo sapiens 
2020-12-22 | E-MTAB-8901 | biostudies-arrayexpress
TranscriptomicsGene expression analysis in gut biopsies of Crohn's Disease patients and patients with Spondylarthropathy
A focussed microarray chip was constructed specifically for studying basal colonic gene expression in patients with Spondyloarthropathy (SpA) and Crohn's disease (CD) (ref: PMID 16476712). These focus microarrays were used 1) to study common changes in gene expression between SpA and CD, providing e...
ORGANISM(S): Homo sapiens 
2010-05-01 | E-GEOD-14442 | biostudies-arrayexpress
MetabolomicsDonor Gut MicrobialDrives Fecal Microbiota Transplantation Efficacy in ulcerative colitis

Fecal microbiota transplantation (FMT) has emerged as a promising therapeutic strategy for Inflammatory Bowel Disease (UC), though its clinical success appears contingent upon donor microbiota engraftment degree. While microbial colonization dynamics remain poorly understood, our study identifies...

2026-01-11 | MTBLS12531 | MetaboLights
TranscriptomicsPurified intestinal epithelial cells from foetal and paediatric gut
CD326+ sorted intestinal epithelial cells from foetal (9-12 wk gestational age) small bowel and large bowel, CD326+ sorted intestinal epithelial cells from mucosal biopsies of paediatric (5-15 years of age) terminal illeum, ascending colon and sigmoid colon FPG=Foetal proximal gut, FDG=Foetal distal...
ORGANISM(S): Homo sapiens 
2015-09-15 | E-MTAB-3704 | biostudies-arrayexpress
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