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ProteomicsAsparaginase and GSK3A inhibitor treatment of CCRF-CEM cells
Resistance to asparaginase, an antileukemic enzyme that depletes asparagine, is a common clinical problem. Using a genome-wide CRISPR/Cas9 screen, we found a synthetic lethal interaction between Wnt pathway activation and asparaginase in acute leukemias resistant to this enzyme. Wnt pathway activa...
ORGANISM(S): Homo sapiens (Human) 
2019-03-29 | PXD013061 | Pride
Gsk3 Leukemia Asparaginase 
UnknownLumbopelvic dysfunction and depression in pregnant women: a cross-sectional study.
Not available
S-EPMC12764017 | biostudies-literature
ProteomicsThe Trypanosoma cruzi Antigen and Epitope Atlas: fine characterization of antibody specificities in human Chagas Disease patients across human populations
These assays represent antibody-binding assays to analyze seroprevalence of antigens and epitopes at the individual level and also to perform fine epitope mapping characterizations. In this screening 392,299 peptides derived from reactive (antigenic) regions of Trypanosoma cruzi proteins were displa...
ORGANISM(S): Homo sapiens 
2022-08-20 | E-MTAB-11655 | biostudies-arrayexpress
ProteomicsThe Trypanosoma cruzi Antigen and Epitope Atlas: discovery of antibody specificities in human Chagas Disease patients across human populations
These assays represent an antigen discovery screening, and epitope mapping characterization. In this screening two complete proteomes from Trypanosoma cruzi, from two different strains (CL-Brener, Sylvio X10), were displayed in the form of short peptides (tiling array, overlapped) and assayed with p...
ORGANISM(S): Homo sapiens 
2022-08-20 | E-MTAB-11651 | biostudies-arrayexpress
GenomicMechanisms of Chemotherapy Resistance in T-ALL

The goals of this study are to unravel the molecular mechanisms underlying leukemic transformation and chemotherapy resistance in T-cell acute lymphoblastic leukemia (T-ALL). Towards this end, a cohort of T-ALL lymphoblast specimens was collected at the time of initial T-ALL diagnosis (prior to t...

phs001513 | dbGaP
Proteomics,MultiomicsCyclin C-CDK3/8/19 kinases play a tumor-suppressive role in vivo
Cyclin C was cloned as a growth-promoting G1 cyclin1,2, and several studies postulated a role for cyclin C in driving cell proliferation3-8 . Moreover, cyclin C, together with its kinase partner, the cyclin-dependent kinase CDK8, is believed to represent an essential component of basal transcrip...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-29 | MSV000080728 | MassIVE
UnknownPrognostic performance of the Age, PaO<sub>2</sub>/FiO<sub>2</sub> Ratio, and Plateau Pressure Score (APPS) for mortality in patients with COVID-19-associated acute respiratory distress syndrome admitted to an intensive care unit.
Not available
S-EPMC11645718 | biostudies-literature
ProteomicsK48-Ubiquitin IP-MS of Jurkat leukemia cells treated with asparaginase
We have shown that drug-resistant leukemias rely on protein degradation through the ubiquitin proteasome pathway to survive during asparaginase therapy. Our studies support the model that this catabolic source of amino acids is upregulated in response to amino acid starvation. To investigate wheth...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2022-04-08 | MSV000089226 | MassIVE
UnknownOccult hepatitis B virus infection among Mexican human immunodeficiency virus-1-infected patients.
Not available
S-EPMC4188904 | biostudies-literature
UnknownAnnotated Peruvian banknote dataset for currency recognition and classification.
Not available
S-EPMC10641131 | biostudies-literature
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