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TranscriptomicsNCI-H1299 cell line transfected with human DENND2D and vector
Gene expression for NCI-H1299 cell line transfected with human DENND2D and vector (pcDNA3.1/V5-His TOPO TA vector) respectively. The microarray experiment was designed to perform four replicates for each H1299-DENND2D and H1299-vector sample. cRNA used in replication 1 and 2 was from the same label...
ORGANISM(S): Homo sapiens 
2010-05-27 | E-GEOD-16890 | biostudies-arrayexpress
TranscriptomicsH1299 cells: p53 transcriptional response in hypoxia
Transcriptional profiling of H1299 non-small cell lung carcinoma cells transfected with either wt p53 or mut(175) p53 driven by the 5xHRE promoter (5 repeats of hypoxia-inducible factor response elements) and treated for 16 h with normoxia (21% O2) or hypoxia(<0.1% O2). 5xHRE promoter ensures that p...
ORGANISM(S): Homo sapiens 
2014-01-08 | E-GEOD-53893 | biostudies-arrayexpress
TranscriptomicsMicroRNA expression data from H1299 cells
We explored the biological effects of AGO2 downregulation on the expression of miRNAs in human NSCLC cells. Using AGO2 siRNA as a positive control, we overexpressed miR-138 in H1299 cells to observe changes in the miRNA profile using an miRNA microarray assay. Total RNAs were extracted from H1299 ce...
ORGANISM(S): Homo sapiens 
2015-06-05 | E-GEOD-69561 | biostudies-arrayexpress
TranscriptomicsRNA-seq of H1299 cells stably transfected with empty vector or the p53 mutant R273H.
This experiment aimed to determine the genes that were upregulated when mutant p53 (R273H) was expressed. We used H1299 lung cancer cells that are endogenously p53-null and overexpressed the p53 mutant.
ORGANISM(S): Homo sapiens 
2017-04-16 | E-MTAB-5652 | biostudies-arrayexpress
TranscriptomicsCoordinated regulation of MAPK signaling pathway and microRNA in response to ionizing radiation in lung cancer cells
microRNA regulates cellular responses to ionizing radiation (IR) through the translational control of target genes. We analyzed time-series changes in microRNA expressions upon γ-irradiation in H1299 lung cancer cell lines using microarray. Significantly changed microRNAs were selected based on ANOV...
ORGANISM(S): Homo sapiens 
2011-09-13 | E-GEOD-30075 | biostudies-arrayexpress
ProteomicsExosomes of p53 mutant H1299 cells
Proteome of exosomes purified from H1299-p53R273H (mutant) and H1299-p53-/- cells, which found the levels of Podocalyxin altered in p53-mutant cells.
ORGANISM(S): Homo sapiens (Human) 
2018-12-04 | PXD011241 | Pride
Human  h1299  cancer  podocalyxin  p53 
TranscriptomicsTranscriptomic analysis of H1299, HEK293T and CHO-K1 treated with Filgotinib
RNA-sequencing was performed on H1299, HEK293T and CHO-K1 transfected with plasmids expressing EGFP and mKate in an open loop circuit (OL), w/wo compound supplementation, or with iFFL circuit.mKate has target sites for miRNAs highly expressed in the different cell lines (miRNA31 for H1299, miRNA221 ...
ORGANISM(S): Homo sapiens 
2025-07-24 | E-MTAB-15146 | biostudies-arrayexpress
TranscriptomicsExpression data for cultured NCI-H1299 parental and spheroid cells as well as their derived xenograft models
Current approaches to the preclinical investigation for novel cancer therapies rely heavily on the use of traditional cancer cell lines maintained in serum-containing conditions. The discrepancy between promising preclinical efficacy and clinical outcome of most novel anticancer agents emphasizes a ...
ORGANISM(S): Homo sapiens 
2010-07-30 | E-GEOD-21612 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of human p73 over-expressing H1299 cells
The integral role of p53 in tumor suppression has promted many laboratories to perform extensive analyses of signaling pathways downstream of the p53 family of sequence-specific DNA binding transcription factors (p53 and its homologs p63 and p73). Despite the ability of p73 to regulate many p53 fam...
ORGANISM(S): Homo sapiens 
2008-10-20 | E-GEOD-11626 | biostudies-arrayexpress
TranscriptomicsExpression data from EGR1-transfected H1299 cells vs normal H1299 cells
The functions of EGR1, a multifunctional transcription factor, in prostate cancer are well documented. However, little is known about the functions of EGR1 in lung cancer. we observed the function of EGR1 in non-small cell lung carcinoma (NSCLC) and identified the genes that influence cell fate and ...
ORGANISM(S): Homo sapiens 
2013-09-17 | E-GEOD-50913 | biostudies-arrayexpress
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