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TranscriptomicsHistone H3 lysine 56 acetylation is linked to the core transcriptional network in human embryonic stem cells
Lysine 56 acetylation in the helical core of histone H3 opens yeast chromatin and enables histone gene transcription, DNA replication, DNA repair, and prevents epigenetic silencing. While K56Ac is globally abundant in yeast and flies its presence has been uncertain in mammals. We show here using mas...
ORGANISM(S): Homo sapiens 
2009-02-09 | E-GEOD-14749 | biostudies-arrayexpress
GenomicsHistone H3K4 Demethylation is Negatively Regulated by Histone H3 Acetylation in S. cerevisiae
Histone H3 lysine 4 tri-methylation (H3K4me3) is a hallmark of transcription initiation, but how H3K4me3 is demethylated during gene repression is poorly understood. Jhd2, a JmjC domain protein, was recently identified as the major H3K4me3 histone demethylase (HDM) in S. cerevisiae. While JHD2 is ...
ORGANISM(S): Saccharomyces cerevisiae 
2012-11-05 | E-GEOD-41424 | biostudies-arrayexpress
TranscriptomicsActive chromatin domains are defined by acetylation islands revealed by genome-wide mapping
The identity and developmental potential of a human cell is specified by its epigenome that is largely defined by patterns of chromatin modifications including histone acetylation. Here we report high-resolution genome-wide mapping of diacetylation of histone H3 at Lys 9 and Lys 14 in resting and ac...
ORGANISM(S): Homo sapiens 
2007-02-05 | E-GEOD-6974 | biostudies-arrayexpress
TranscriptomicsHistone H3 lysine 4 acetylation-methylation dynamics define breast cancer subtypes [RNA-seq]
The onset and progression of breast cancer are linked to genetic and epigenetic changes that alter the normal programming of cells. Epigenetic modifications of DNA and histones contribute to chromatin structure that results in the activation or repression of gene expression. Several epigenetic pathw...
ORGANISM(S): Homo sapiens 
2016-02-10 | E-GEOD-75168 | biostudies-arrayexpress
TranscriptomicsHistone H3 lysine9 acetylation, rather than lysine4 trimethylation, marks meiotic recombination hotspots and promotes recombination initiation in fission yeast
Histone modifications are associated with meiotic recombination hotspots, discrete sites with augmented recombination frequency. For example, trimethylation of histone H3 lysine4 (H3K4me3) marks most hotspots in budding yeast and mouse. Modified histones are known to regulate meiotic recombinatio...
ORGANISM(S): Schizosaccharomyces pombe 
2013-03-07 | E-GEOD-31648 | biostudies-arrayexpress
TranscriptomicsCfp1 is required for gene expression dependent H3K4me3 and H3K9 acetylation in embryonic stem cells (RNA-Seq)
Trimethylation of histone H3 lysine 4 (H3K4me3) accumulates at promoters in a gene activity dependant manner. The Set1 complex is responsible for most H3K4me3 in somatic cells and contains the conserved subunit Cfp1, which is implicated in targeting the Set1 complex to CpG islands in mammals. In mou...
ORGANISM(S): Mus musculus 
2014-08-20 | E-GEOD-53489 | biostudies-arrayexpress
TranscriptomicsING4 ChIP-chip in HT1080 cells
Aberrations in chromatin dynamics play a fundamental role in tumorigenesis, yet relatively little is known of the molecular mechanisms linking histone lysine methylation to neoplastic disease. ING4 (Inhibitor of Growth 4) is a native subunit of an HBO1 histone acetyltransferase (HAT) complex and a t...
ORGANISM(S): Homo sapiens 
2010-05-17 | E-GEOD-13412 | biostudies-arrayexpress
GenomicsGATA4 represses an ileal program of gene expression in the proximal small intestine by inhibiting the acetylation of histone H3, lysine 27.
GATA4 is expressed in the proximal 85% of small intestine where it promotes a proximal intestinal ('jejunal') identity while repressing a distal intestinal ('ileal') identity, but its molecular mechanisms are unclear. Here, we tested the hypothesis that GATA4 promotes a jejunal versus ileal identity...
ORGANISM(S): Mus musculus 
2015-05-16 | E-GEOD-68957 | biostudies-arrayexpress
TranscriptomicsChromatin immunoprecipitation of yeast using anti-H3C and anti-K56 antibodies
Chromatin immunoprecipitation DNA by H3 K56 acetylation antibody
ORGANISM(S): Saccharomyces cerevisiae 
2007-09-28 | E-MEXP-1248 | biostudies-arrayexpress
GenomicsChIP-seq analysis of H3K9 acetylation enrichment in hESCs and day 8 neural progenitor cells
H3K9 acetylation was enriched in pluripotency genes in hESCs and in neural genes in neural progenitor cells Examination of H3K9 acetylation distributions in hESCs and neural progenitor cells
ORGANISM(S): Homo sapiens 
2015-03-11 | E-GEOD-66778 | biostudies-arrayexpress
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