Sort   by:  
 Page size 
MetabolomicsGluconeogenic enzyme PCK1 supports S-adenosylmethionine biosynthesis and H3K9me3 to suppress HCC progression
Deciphering the crosstalk between metabolic reprogramming and epigenetic regulation is a promising strategy for cancer therapy. In this study, we discovered that the gluconeogenic enzyme PCK1 fuels the generation of S-adenosylmethionine (SAM) through the serine synthesis pathway. The methyltransfera...
2025-08-09 | MTBLS7651 | MetaboLights
TranscriptomicsCrosstalk between gene body DNA methylation, H3K9me3 and H3K36me3 chromatin marks and transcription [HuGene-1_0-st]
This is one of expressional parts of the study. These data were correlated to epigenetic marks and CG density of genes in analyzed cells. The whole study has a following summary: To elucidate possible roles of DNA methylation and chromatin marks in transcription, we performed epigenetic profiling of...
ORGANISM(S): Homo sapiens 
2011-03-31 | E-GEOD-26019 | biostudies-arrayexpress
GenomicsEpigenetic profiling of well differentiated and dedifferentiated liposarcoma identifies H3K9me3 and Kruppel-like factor 6 (KLF6) as determinants of aggressiveness in sarcoma (ChIP-seq)
Little is known about the epigenomics of liposarcoma (LPS). Here, we profiled the global expression of 9 epigenetic marks in well differentiated (WD) and dedifferentiated (DD) LPS from 151 patients and found increased H3K9me3 among DDLPS tumors. We performed ChIP-seq and gene expression profiling ...
ORGANISM(S): Homo sapiens 
2015-08-04 | E-GEOD-57749 | biostudies-arrayexpress
TranscriptomicsEpigenetic profiling of well differentiated and dedifferentiated liposarcoma identifies H3K9me3 and Kruppel-like factor 6 (KLF6) as determinants of aggressiveness in sarcoma (expression)
Little is known about the epigenomics of liposarcoma (LPS). Here, we profiled the global expression of 9 epigenetic marks in well differentiated (WD) and dedifferentiated (DD) LPS from 151 patients and found increased H3K9me3 among DDLPS tumors. We performed ChIP-seq and gene expression profiling ...
ORGANISM(S): Homo sapiens 
2015-08-04 | E-GEOD-57750 | biostudies-arrayexpress
ProteomicsNuclear polysaccharides maintain H3K9me3-heterochromatin and genomic stability
Polysaccharides are traditionally confined to the cell surface and extracellular space, whereas their nuclear roles remain unclear. Here, we show that N-glycans are present in the nucleus and modify inner nuclear membrane (INM) proteins across multiple cell types. Disruption of INM protein N-glycosy...
ORGANISM(S): Mus Musculus 
2025-12-30 | PXD072505 |
GenomicsGenome-wide maps of H3K9me3 in control ESCs and Rif1 knockdown ESC.
We found that Rif1 depletion leads to reduced H3K9me3 levels at 1/3 of the H3K9me3-enriched genomic regions (H3K9me3 peaks), and that reduced H3K9me3 de-represses Zscan4 and other genes that are specific to the 2-Cell stage embryo. Examination of H3K9me3 histone modifications in 2 cell types.
ORGANISM(S): Mus musculus 
2014-02-13 | E-GEOD-54947 | biostudies-arrayexpress
TranscriptomicsSuv39h-dependent H3K9me3 represses intact retrotransposons in mouse embryonic stem cells
Heterochromatin is required to restrict aberrant expression of retrotransposons, but it remains poorly defined due to the underlying repeat-rich sequences. We dissected Suv39h-dependent histone H3 lysine 9 trimethylation (H3K9me3) by genome-wide ChIP-sequencing in mouse embryonic stem cells (ESCs). ...
ORGANISM(S): Mus musculus 
2014-06-26 | E-GEOD-57092 | biostudies-arrayexpress
TranscriptomicsDNA methylation and SETDB1/H3K9me3 regulate predominantly distinct sets of genes, retroelements and chimaeric transcripts in mouse ES cells
DNA methylation and histone H3 lysine 9 trimethylation (H3K9me3) play important roles in silencing of genes and retroelements. However, a comprehensive comparison of genes and repetitive elements repressed by these pathways has not been reported. Here we show that in mouse embryonic stem cells (mESC...
ORGANISM(S): Mus musculus 
2011-05-21 | E-GEOD-29413 | biostudies-arrayexpress
GenomicsThe chromatin remodeler ATRX binds to atypical chromatin domains at the 3’ exons of ZNF genes to preserve H3K9me3 enrichment
Here, we report that ATRX co-localizes with the H3K9-methyl transferase SETDB1 (also known as ESET), the co-repressor TRIM28 (also known as KAP1), and the transcription factor ZNF274 at 3’ exons of Zinc Finger Genes (ZNFs) containing an atypical H3K9me3/H3K36me3 chromatin signature. Disruption of ...
ORGANISM(S): Homo sapiens 
2016-04-05 | E-GEOD-70920 | biostudies-arrayexpress
ProteomicsRIF1 orchestrates a multi-step restoration of post-replicative H3K9me3
DNA replication causes the dilution of parental histones along with their specific post-translational modifications. The kinetics of restoring these marks on newly incorporated histones dictate how quickly genomic domains regain their epigenetic identity after replication. H3K9me3 is restored extrem...
ORGANISM(S): Mus musculus (Mouse) 
2026-09-08 | PXD066722 | Pride
Dna replication Tmt Lc-ms 
Sort   by:  
 Page size