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TranscriptomicsComparison of BRG1 reexpression, TSA treatment and 5dAzaC treatment on gene expression in human NCI-H522 NSCLC cells
Transcription was assessed in the human H522 NSCLC cell line after reexpression of BRG1, one of the mutually exclusive subunits of the SWI/SNF chromatin remodeling complex, by adenovirus infection, after treatment with 5 micromolar 5-deAzacytidine or after treatment with 100nM Trichostatin A. Contr...
ORGANISM(S): Homo sapiens 
2014-01-13 | E-GEOD-54033 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human NCI-H522
The transcription factors Smad2 and Smad3 mediate a large set of genes responses induced by the cytokine TGFβ, but the extent to which their function depends on chromatin remodeling remains to be defined. We observed interactions between these two Smads and BRG1, BAF250b, BAF170 and BAF155, which a...
ORGANISM(S): Homo sapiens 
2008-04-05 | E-GEOD-10847 | biostudies-arrayexpress
GenomicsTranscriptome analysis of SARS-CoV-2 infected H522 human lung adenocarcinoma cells
Transcriptome analysis of SARS-CoV-2 infected H522 human lung adenocarcinoma cells
PRJNA686659 | ENA
TranscriptomicsTranscriptome analysis of SARS-CoV-2 infected H522 human lung adenocarcinoma cells
Purpose: The goal of this study is to define the transcriptional response of H522 cells to SARS-CoV-2 infection. Methods:H522 cells were infected with SARS-CoV-2 at varying multiplicities of infection and samples processed for RNA-seq at 4, 24, 48, 72 and 96 hours post-infection. Results: We provide...
ORGANISM(S): Homo sapiens 
2021-01-31 | GSE163547 | GEO
ProteomicsACE2 independent SARS-CoV-2 infection of a human lung cell line
In a screen of human upper airway cell lines, we identified the H522 lung adenocarcinoma cells as naturally permissive to SARS-CoV-2 infection despite no evidence of ACE2 or TMPRSS2 expression. Temporally resolved transcriptomic and proteomic profiling of H522 cells revealed consistent alterations i...
ORGANISM(S): Homo sapiens (Human) 
2022-03-07 | PXD023754 | Pride
Sars-cov-2 Covid19 H522 
TranscriptomicsIdentification of SOX4 novel transcriptional targets.
The SOX4 gene belongs to a family of transcription factors and we previously unveiled SOX4 gene amplification and over-expression in a subset of lung cancers, indicating it may constitute a driver oncogene. Here, we searched for SOX4 transcriptional targets and investigate their involvement in lung ...
ORGANISM(S): Homo sapiens 
2011-11-18 | E-GEOD-31612 | biostudies-arrayexpress
TranscriptomicsComparison of BRG1 reexpression, TSA treatment and 5dAzaC treatment on gene expression in human NCI-H522 NSCLC cells
Transcription was assessed in the human H522 NSCLC cell line after reexpression of BRG1, one of the mutually exclusive subunits of the SWI/SNF chromatin remodeling complex, by adenovirus infection, after treatment with 5 micromolar 5-deAzacytidine or after treatment with 100nM Trichostatin A. Contro...
ORGANISM(S): Homo sapiens 
2014-01-13 | GSE54033 | GEO
TranscriptomicsH522 lung cancer cells' TGFbeta response was restored by putting back BRG1 and TGFbRII
The transcription factors Smad2 and Smad3 mediate a large set of genes responses induced by the cytokine TGFβ, but the extent to which their function depends on chromatin remodeling remains to be defined. We observed interactions between these two Smads and BRG1, BAF250b, BAF170 and BAF155, which ar...
ORGANISM(S): Homo sapiens 
2008-03-18 | GSE10847 | GEO
GenomicsEffect of ionizing radiation on FaDu, H522, HSC2, and SCC4 cancer cells
Effect on gene expression after 4 days of a single, 15 Gy dose of ionizing X ray radiation on H522 human lung cancer, and FaDu, HSC2 and SCC4 human head and neck cancer cell-lines
PRJEB20193 | ENA
GenomicsLINC00261 is an epigenetically-regulated tumor suppressor that is essential for activation of the DNA damage response [H522-LINC00261 RNA-seq data set]
LINC00261 is an epigenetically-regulated tumor suppressor that is essential for activation of the DNA damage response [H522-LINC00261 RNA-seq data set]
PRJNA433043 | ENA
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