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TranscriptomicsTHE GOOD, THE BAD, AND THE TOXIC: DECIPHERING HORMESIS IN DAPHNIA MAGNA EXPOSED TO AN ENERGETIC COMPOUND
Hormesis is a dose response phenomenon characterized by a stimulation of an organismal response at low doses of a chemical and inhibition of the response (toxicity) at a higher dose. In the present study, Daphnia magna were exposed to the energetic compound 2,4,6-trinitrotoluene (TNT) for 21 days, ...
ORGANISM(S): Daphnia magna 
2013-02-01 | E-GEOD-43960 | biostudies-arrayexpress
TranscriptomicsComparison of genomic, morphological, and behavioral responses among fathead minnow (Pimephales promelas ) and zebrafish (Danio rerio) to acute RDX exposure
Paper Abstract. Extrapolating toxicological sensitivity information across species can require the use of highly conservative safety factors as prescribed by ecological risk assessment protocols. The objective of our study was to use multipule factors to understand the dynamics of stress responses ...
ORGANISM(S): Danio rerio 
2011-02-08 | E-GEOD-27067 | biostudies-arrayexpress
TranscriptomicsInvestigating RDX neurotoxicity in rat brain using gene expression analysis and transcriptional network modeling
ABSTRACT: The central nervous system is remarkably plastic in its ability to recover from trauma. We examined recovery from hexahydro-1,3,5-trinitrotriazine (RDX) induced seizures in rat through changes in transcriptional networks. Transcriptional networks from time series experiments provide a goo...
ORGANISM(S): Rattus norvegicus 
2011-05-31 | E-GEOD-27042 | biostudies-arrayexpress
TranscriptomicsIntegrated approach to explore the mechanisms of aromatase inhibition and recovery on fathead minnow ovaries
Aromatase, a member of the cytochrome P450 superfamily, is a key enzyme in estrogen synthesis and is responsible for the aromatization of androgens into estrogens. Here, we used an integrated approach to better understand the effects of aromatase inhibition as well as the mechanisms involved in the ...
ORGANISM(S): Pimephales promelas 
2013-11-01 | E-GEOD-51961 | biostudies-arrayexpress
TranscriptomicsIdentification of metabolic pathways in Daphnia magna exposed to selective serotonin reuptake inhibitors using transcriptomic, immunocytochemistry and physiological responses.
Assessing the risks of long-term exposure to low doses of pharmaceuticals is an identified research need, particularly for those that may act as neural disruptors in non-vertebrate species. Selective serotonin reuptake inhibitors (SSRIs) act by blocking the re-uptake of serotonin in the nerve synaps...
ORGANISM(S): Daphnia magna 
2013-03-15 | E-GEOD-45053 | biostudies-arrayexpress
TranscriptomicsToxicogenomic analysis of ionic silver and silver nanoparticles on the fathead minnow and implications to human health
Nanoparticles are compounds of emerging concern with largely unknown risks for human and ecological health. It is crucial to evaluate their potential biological impact to prevent unintended adverse effects on human health and the environment. We analyzed the transcriptional effects of polyvinylpyrro...
ORGANISM(S): Pimephales promelas 
2013-11-01 | E-GEOD-46520 | biostudies-arrayexpress
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