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ProteomicsRepurposing human kinase inhibitors to create an antibiotic active against drug-resistant Staphylococcus aureus
To combat methicillin-resistant Staphylococcus aureus (MRSA) infections novel drugs are desperately needed. From a screen, we found that the anti-cancer drug sorafenib effectively kills MRSA strains. By synthetic variation of key structural features, we identified a potent analog, PK150, exhibiting ...
ORGANISM(S): Staphylococcus aureus 
2019-09-09 | PXD012946 | Pride
Full proteome Affinity-based protein profiling (afbpp) Q exactive plus Chemical proteomics Staphylococcus aureus subsp. aureus nctc 8325 Secretome Surfaceome Orbitrap fusion 
ProteomicsBioresponsive pseudoGlucosinolates (psGSLs) release Isothiocyanates (ITCs) in the Presence of Nitroreductases
Glucosinolates (GSLs) are secondary metabolites produced as part of an herbivore defence system in plants of the order Brassicales. GSLs release isothiocyanates (ITCs) upon activation by the myrosinase. Beyond their herbivore feeding deterrent properties, these ITCs have multiple interesting bioacti...
ORGANISM(S): synthetic construct (code 12) 
2026-09-07 | PXD065044 | Pride
Bioresponsive molecules Pseudoglucosinolates Artificial gluscosinolates Nitroreductase Isothiocanantes 
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