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ProteomicsDetection of structure-specific protein–protein interactions of alpha-synuclein
Parkinson’s disease (PD) is a neurodegenerative disorder associated with the accumulation of intraneuronal protein aggregates called Lewy bodies. These inclusions contain aberrantly folded and aggregated alpha-synuclein (aSyn), a key protein involved in the pathology of PD, for which the mechanisms ...
ORGANISM(S): Homo sapiens (Human) 
2024-02-10 | PXD039784 | Pride
Amyloid fibrils Neurodegeneration Structural proteomics Protein-protein interactions Lc-msms Alpha-synuclein Interactome Induced pluripotent stem cell-derived cortical neurons Mass spectrometry Limited proteolysis Parkinson’s disease Proteomics Structure-specific interactions 
UnknownLentiviral gene therapy vector with UCOE stably restores function in iPSC-derived neutrophils of a CDG patient.
Not available
S-EPMC6472893 | biostudies-literature
ProteomicsStructure-function relationship of alpha-synuclein fibrillar polymorphs derived from distinct synucleinopathies (Part 1)
The aggregation of the protein alpha-synuclein (αSyn) is a common feature of multiple neurodegenerative diseases collectively called synucleinopathies, for which the pathobiology is not well understood. The different phenotypic characteristics of the synucleinopathies Parkinson’s disease (PD), Demen...
ORGANISM(S): Homo sapiens (Human) 
2026-06-08 | PXD058124 | Pride
Synucleopathies Structural proteomics  mass spectrometry  chemical surface modification  nhs-biotin  nanolc-msms Amplified synuclein fibrils 
UnknownDifferences in neuronal ciliation rate and ciliary content revealed by systematic imaging-based analysis of hiPSC-derived models across protocols.
Not available
S-EPMC12021924 | biostudies-literature
ProteomicsDetection of structure-specific interactions of Rab GTPases
Protein–protein interactions (PPIs) mediate multiple essential functions and regulatory events in living organisms. The physical interactome of a given protein can be abnormally altered in response to external and internal cues, thus modulating cell physiology and contributing to human pathologies i...
ORGANISM(S): Homo sapiens (Human) 
2024-02-10 | PXD048849 | Pride
Lc-msms Interactome Mass spectrometry Limited proteolysis Structural proteomics Protein-protein interactions Proteomics Rab gtpases Structure-specific interactions 
UnknownLRRK2 Is Recruited to Phagosomes and Co-recruits RAB8 and RAB10 in Human Pluripotent Stem Cell-Derived Macrophages.
Not available
S-EPMC7221108 | biostudies-literature
ProteomicsLimited proteolysis–mass spectrometry detects protein–protein interactions of integral membrane proteins
Integral membrane proteins (IMPs) are permanently embedded within the plasma membrane and execute multiple cellular functions. IMPs constitute important targets, but development of drugs that target IMPs to modulate protein–protein interactions, which mediate their functions, has been challenging. C...
ORGANISM(S): Bos taurus (Bovine) Homo sapiens (Human) 
2024-02-10 | PXD039520 | Pride
Lc-msms Membrane proteins Interactome Mass spectrometry Limited proteolysis Structural proteomics Protein-protein interactions Proteomics Crude membranes 
ProteomicsProbing antigen–antibody interactions using limited proteolysis–mass spectrometry
Protein–protein interactions (PPIs) mediate multiple essential functions and regulatory events in living organisms. The physical interactome of a given protein can be abnormally altered in response to external and internal cues, thus modulating cell physiology and contributing to human pathologies i...
ORGANISM(S): Homo sapiens (Human) 
2024-02-10 | PXD039481 | Pride
Lc-msms Antibody-antigen interaction Interactome Mass spectrometry Respiratory syncytial virus fusion glycoprotein Limited proteolysis Structural proteomics Protein-protein interactions Mammalian cells Proteomics 
UnknownExcess α-synuclein compromises phagocytosis in iPSC-derived macrophages.
Not available
S-EPMC5567139 | biostudies-literature
UnknownA Highly Efficient Human Pluripotent Stem Cell Microglia Model Displays a Neuronal-Co-culture-Specific Expression Profile and Inflammatory Response.
Not available
S-EPMC5470330 | biostudies-literature
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