Sort   by:  
 Page size 
ProteomicsHealthy aging of skeletal muscle: Insights from a combined morphological and multiomic study
Aging impacts on the plasticity and biochemistry of skeletal muscle. For a deeper understanding of skeletal muscle function in aging and sarcopenia, defined as age related muscle decline, the identification of molecular signatures regulating muscle function under physiological conditions is importan...
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD049424 | Pride
Bioinformatics in omics Mitochondria in aging Sarcopenia Muscle proteomics Muscle transcriptomics 
ProteomicsMulti-level profiling unravels mitochondrial dysfunction in Myotonic Dystrophy type 2
Myotonic Dystrophy type 2 (DM2) is an autosomal-dominant, multisystemic disease with a core manifestation of proximal muscle weakness, muscle atrophy, myotonia, and myalgia. The disease-causing CCTG tetranucleotide expansion within the CNBP gene on chromosome 3 leads to an RNA-dominated spliceopathy...
ORGANISM(S): Homo sapiens (Human) 
2024-01-26 | PXD044286 | Pride
Myotonic dystrophy type 2 Repeat expansion disease Proximal myotonic myopathy Mitochondrial dysfunction 
TranscriptomicsExpression profiling of human primary breast cancer tissue before treatment with gemcitabine, epirubicine and docetaxel
Gene expression profiles of human breast cancer tissues from 100 different patients treated with primary systemic chemotherapy (Gemcitabine, Epirubicin and Docetaxel) Keywords: expression profiling Human breast cancer tissues from 100 patients have been used to perform expression profiling analysis...
ORGANISM(S): Homo sapiens 
2006-01-21 | E-GEOD-4056 | biostudies-arrayexpress
UnknownEfficacy and Safety of N-Acetyl-l-Leucine in Children and Adults With GM2 Gangliosidoses.
Not available
S-EPMC9990862 | biostudies-literature
GenomicsUQ Data Access Commitee
Data Access Committee EGAC00001002686
EGAC00001002686 | EGA
TranscriptomicsS080_BrCaRes_Schneeweiss et al.
In patients with primary breast cancer, neoadjuvant chemotherapy with doxorubicin plus pemetrexed followed by docetaxel (AP-D) is associated with a pathologic complete response (pCR) rate of 16.5%, and doxorubicin plus cyclophosphamide followed by docetaxel (AC-D) is associated with a pCR rate of 20...
ORGANISM(S): Homo sapiens 
2014-02-01 | E-TABM-1186 | biostudies-arrayexpress
TranscriptomicsIL13_0-12h_RAIA_et_al
Primary mediastinal B-cell lymphoma (PMBL) and classical Hodgkin lymphoma (cHL) share a frequent constitutive activation of Janus-activated kinase (JAK) / signal transducer and activator of transcription (STAT) signaling pathway. Due to complex non-linear relations within the pathway, key dynamic pr...
ORGANISM(S): Homo sapiens 
2010-12-09 | E-GEOD-23591 | biostudies-arrayexpress
ProteomicsUnravelling MYO9A pathophysiology in CMS allows the identification of a therapeutic intervention concept
Congenital myasthenic syndromes (CMS) are a group of rare, inherited disorders characterised by compromised function of the neuromuscular junction (NMJ), manifesting with fatigable muscle weakness. Mutations in MYO9A were previously identified as causative for CMS but the precise pathomechanism rema...
ORGANISM(S): Mus musculus (Mouse) 
2018-10-24 | PXD007178 | Pride
Lc-msms Myo9a Nsc34 
ProteomicsComplement profiling on sural nerves of patients with chronic inflammatory demyelinating polyneuropathy
Overall, 55 sural nerve biopsies from patients with CIDP (n=36) and CIDP-variants (n=18) were included into the study. Immunohistochemical analysis of the sural nerve specimens showed an aberrant deposition of terminal complement complex C5b-9 on endoneural capillaries in 52 (94%) of patients in add...
ORGANISM(S): Homo sapiens (Human) 
2025-09-29 | PXD056286 | Pride
Proteomics Gene expression Chronic inflammatory demyelinating polyneuropathy  complement profiles  sural nerve 
TranscriptomicsWhole genome gene expression profiles of normo- and dyslipidemic men after fish oil supplementation
Beneficial effects of long-chain omega-3 polyunsaturated fatty acids (n-3 FAs) are generally well-known from epidemiological studies, but the various mechanisms of action are not completely clarified. Regulation of gene expression is one known mechanism of action, but only very limited data of regul...
ORGANISM(S): Homo sapiens 
2012-05-29 | E-GEOD-34898 | biostudies-arrayexpress
Sort   by:  
 Page size