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ModelsRaia2011 - IL13 L1236
This is the model of IL13 induced signalling in L1236 cells described in the article: Dynamic Mathematical Modeling of IL13-Induced Signaling in Hodgkin and Primary Mediastinal B-Cell Lymphoma Allows Prediction of Therapeutic Targets. Raia V, Schillin...
2024-09-02 | BIOMD0000000314 | BioModels
ModelsRaia2010 - IL13 Signalling MedB1
This is the model of IL13 induced signalling in MedB-1 cell described in the article: Dynamic Mathematical Modeling of IL13-Induced Signaling in Hodgkin and Primary Mediastinal B-Cell Lymphoma Allows Prediction of Therapeutic Targets. Raia V, Schilling M, Böhm M, Hahn B, Kowarsch A,...
2024-09-02 | BIOMD0000000313 | BioModels
ModelsDallePezze2016 - Activation of AMPK and mTOR by amino acids (Model 1)
DallePezze2016 - Activation of AMPK and mTOR by amino acids (Model 1) This model is as described in Supplementary Software 2 of the reference publication: SBML model including only the canonical amino acid input on mTORC1. This model is described in the article: A systems study reveals ...
2017-05-18 | MODEL1705030000 | BioModels
ModelsDallePezze2016 - Activation of AMPK and mTOR by amino acids (Model 2)
DallePezze2016 - Activation of AMPK and mTOR by amino acids (Model 2) This model is as described in the Supplementary Software 2 of the reference publication:  SBML model including four amino acids input in the network (simple p70-S6K module). This model is described in the article:...
2017-05-18 | MODEL1705030001 | BioModels
ModelsDallePezze2016 - Activation of AMPK and mTOR by amino acids
DallePezze2016 - Activation of AMPK and mTOR by amino acids (Model 3) This model is as described in the Supplementary Software 3 of the reference publication: SBML model similar to Model S2, but including a more complex p70-S6K module. This model is described in the article: A...
2024-09-02 | BIOMD0000000640 | BioModels
ProteomicsContext-dependent regulatory mechanisms control site-specific information processing within the MEK/ERK module
The impact of the cellular context and receptor type on the dynamics of phosphorylation cycles in signaling pathways are unclear. We employ an unbiased approach to identify network alterations that explain phosphorylation dynamics of the MEK/ERK module in response to hepatocyte growth factor or inte...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-29 | MSV000080803 | MassIVE
ProteomicsValidation of known and novel AKT, S6K and RSK targets by targeted MS
Using the global SILAC and label-free phosphoproteomics experiments as a basis, an inclusion list for validation of known and novel AKT, RSK and S6K targets comprising the RxRxxp[ST] motif was generated. Samples were analyzed by PRM-MS.
ORGANISM(S): Mus Musculus 
2023-02-27 | PXD035962 | panorama
ProteomicsIGF-1 stimulated C2 skeletal myotube phosphoproteome
Skeletal muscle is known to adapt dynamically to changes in workload by regulatory processes of the phosphatidylinositide 3-kinase (PI3K)/Akt pathway. We performed a global quantitative phosphoproteomics analysis of contracting mouse C2 myotubes treated with insulin growth factor 1 (IGF-1) as contro...
ORGANISM(S): Mus musculus (Mouse) 
2020-05-25 | PXD016721 | Pride
Silac Phospho-proteomics C2 Myotubes 
ProteomicsFilamin C domain 18-21 in vitro kinase assay
In vitro kinase assay with human filamin C domain 18-21 recombinantly expressed in E.coli, purified by Ni2+-NTA beads and incubated with PKC alpha, Akt or a combination of both to identify kinase specific phosphorylation sites.
ORGANISM(S): Homo sapiens (Human) Escherichia coli 
2020-05-25 | PXD008893 | Pride
Filamin c Akt In vitro kinase assay Pkb Pkcalpha 
ProteomicsFILIP1 CT pull-down
FILIP1 was identified as potential new filamin C interaction partner by a SILAC-based BioID experiment. Interaction of the two protein via the carboxy-terminal end of FILIP and domain 18-21 of filamin C was prooven by yeast-2-hybrid sreens and dot-blot assays, respectively. To verify this interactio...
ORGANISM(S): Mus musculus (Mouse) 
2022-06-06 | PXD008875 | Pride
C2c12 myotubes Filip1 Filamin c 
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