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TranscriptomicsSuv4-20h Histone Methyltransferases Promote Neuroectodermal Differentiation by Silencing the Pluripotency-Associated Oct-25 Gene
Post-translational modifications (PTMs) of histones exert fundamental roles in regulating gene expression. During development, groups of PTMs are constrained by unknown mechanisms into combinatorial patterns, which facilitate transitions from uncommitted embryonic cells into differentiated somatic c...
ORGANISM(S): Xenopus laevis 
2013-02-06 | E-GEOD-41256 | biostudies-arrayexpress
ProteomicsStrength of a “single-tube” protocol for protein isolation from multiple cell fractions shown for the plant pathogen Xanthomonas campestris pv. campestris B100 with a focus on proteins involved in the biosynthesis of the exopolysaccharide xanthan
Xanthomonas campestris pv. campestris (Xcc) B100 is a phytopathogenic bacterium, which uses xanthan, a secreted heterogeneous exopolysaccharide in both stages of infection of Brassicaceae. Until now, proteome analysis of Xcc lacking a detailed view on the proteins involved in xanthan biosynthesis. P...
ORGANISM(S): Xanthomonas campestris pv. campestris str. B100 
2022-02-16 | PXD027261 | Pride
“single-tube” protocol  lfq analysis  multiple cell fraction analysis  xanthomonas campestris - xanthan biosynthesis  qexactive plus 
ProteomicsReduction in synaptic vesicle proteins but increase in proteins involved in basic cell function in cerebral cortices without the endosomal SNARE proteins Vti1a and Vti1b
Absence of the endosomal SNAREs vti1a and vti1b results in perinatal death and severe neuronal phenotypes in mice while lack of one of these proteins results in minor phenotypes. Proteomic differences were investigated to obtain a deeper insight into processes in which Vti1a and Vti1b are involved. ...
ORGANISM(S): Mus musculus (Mouse) 
2026-03-31 | PXD066845 | Pride
Membrane traffic Snare Endosome Neurodegeneration Proteome 
TranscriptomicsTranslocations Activating IRF4 Identify a Subtype of Germinal-Center-Derived B-cell Lymphoma Affecting Predominantly Children and Young Adults
Background: Germinal center B-cell (GCB) lymphomas are common in children and adults. The prognosis strongly depends on age. Subgroups of GCB-lymphomas are characterized by chromosomal translocations affecting immunoglobulin (IG) loci leading to oncogene deregulation. Methods: Novel IG translocation...
ORGANISM(S): Homo sapiens 
2011-06-24 | E-GEOD-22470 | biostudies-arrayexpress
UnknownA syndromic neurodevelopmental disorder caused by rare variants in PPFIA3.
Not available
S-EPMC10806447 | biostudies-literature
UnknownGene expression imputation across multiple brain regions provides insights into schizophrenia risk.
Not available
S-EPMC7034316 | biostudies-literature
UnknownMapping genomic loci implicates genes and synaptic biology in schizophrenia.
Not available
S-EPMC9392466 | biostudies-literature
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