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ModelsWilkie2013r - immune-induced cancer dormancy and immune evasion-resistance
The paper describes a model of immune-induced cancer dormancy and immune evasion with resistance. Created by COPASI 4.25 (Build 207) This model is described in the article: Mathematical models of immune-induced cancer dormancy and the emergence of immune evasion Kathleen P. Wilkie and Philip Hah...
2024-09-02 | BIOMD0000000752 | BioModels
Immuno-oncology 
ModelsWilkie2013b - immune-induced cancer dormancy and immune evasion-basic
The paper describes a basic model of immune-induced cancer dormancy and immune evasion. Created by COPASI 4.25 (Build 207) This model is described in the article: Mathematical models of immune-induced cancer dormancy and the emergence of immune evasion Kathleen P. Wilkie and Philip Hahnfeldt Int...
2024-09-02 | BIOMD0000000751 | BioModels
Immuno-oncology 
TranscriptomicsAge and Space Irradiation Modulate Tumor Progression: Implications for Carcinogenesis Risk
Age plays a major role in tumor incidence and is an important consideration when modeling the carcinogenesis process or estimating cancer risks. Epidemiological data show that from adolescence through middle age, cancer incidence increases with age. This effect is commonly attributed to a lifetime a...
ORGANISM(S): Mus musculus 
2013-06-13 | E-GEOD-45606 | biostudies-arrayexpress
TranscriptomicsProton irradiation augments the reduction in tumor progression observed with advanced age
Proton irradiation is touted for its improved tumor targeting due to the physical advantages of ion beams for radiotherapy. Recent studies from our laboratory have shown that, in addition to targeting advantages, proton irradiation can inhibit angiogenic and immune factors and thereby modulate tumor...
ORGANISM(S): Mus musculus 
2014-01-01 | E-GEOD-45609 | biostudies-arrayexpress
TranscriptomicsProton Irradiation Impacts Age Driven Modulations of Cancer Progression Influenced by Immune System Transcriptome Modifications from Splenic Tissue
Age plays a crucial role in the interplay between tumor and host; with further perturbations induced by irradiation. Proton irradiation on tumors induces biological modulations including inhibition of angiogenic and immune factors critical to “hallmark” processes impacting tumor development, in addi...
ORGANISM(S): Mus musculus 
2015-06-22 | E-GEOD-67243 | biostudies-arrayexpress
TranscriptomicsHost Age is a Systemic Regulator of Gene Expression Impacting Cancer Progression
Given that aging is the major determinant of cancer incidence, and that cancer incidence is dictated in large part by processes modulating progression of existing subclinical cancers, we demonstrate that aging may be an organizing axis for identifying cancer progression-modulating processes. This wo...
ORGANISM(S): Mus musculus 
2015-03-03 | E-GEOD-66414 | biostudies-arrayexpress
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