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TranscriptomicsThe BET inhibitor JQ1 selectively impairs the tumour response to hypoxia and downregulates CA9 and angiogenesis in triple receptor negative breast cancer
This study aimed to investigate whether the BET inhibitor JQ1 could alter the hypoxia-induced upregulation of gene expression and have an anti-tumour effect associated with this mechanism. We showed JQ1 downregulates 44% of hypoxia upregulated genes, including CA9 and VEGF-A. We demonstrated that JQ...
ORGANISM(S): Homo sapiens 
2016-03-31 | E-MTAB-4604 | biostudies-arrayexpress
TranscriptomicsOverexpression of non-degradable SAS-6 KEN box mutant in RPE-1 cells
Stable clones of RPE-1 cells expressing tetracycline-inducible wild type SAS-6 or SAS-6ND were obtained via lentiviral gene transduction with the pLVX tet-on Advanced inducible gene expression system (Clontech). Stable expressors were derived by selection with 5 μg/mL puromycin (Sigma-Aldrich, UK). ...
ORGANISM(S): Homo sapiens 
2025-01-27 | E-MTAB-13783 | biostudies-arrayexpress
UnknownIs the fire even bigger? Burnout in 800 medical and nursing students in a low middle income country.
Not available
S-EPMC11361430 | biostudies-literature
TranscriptomicscirDNA methylome analysis in prostate cancer
DNA modification profiling of circulating DNA (cirDNA) from plasma samples from prostate cancer patients (T2-3N0Mx), benign prostatic hyperplasia and control individuals Epigenetic differences are a common feature of many diseases, including cancer, and disease-associated changes have even been dete...
ORGANISM(S): Homo sapiens 
2012-07-09 | E-GEOD-36195 | biostudies-arrayexpress
UnknownDevelopment of clinical practice guidelines and primary care referral pathways for management of otorhinolaryngological conditions in Pakistan.
Not available
S-EPMC11881372 | biostudies-literature
TranscriptomicsIdentification and Correction of Amplification Protocol Bias in Microarray Studies
mRNA abundance microarrays are the most widely used high-throughput technology for functional genomics. But despite this extensive characterization, and despite their wide-spread adoption in discovery research, the uptake of microarrays as clinical diagnostic tools remains relatively limited due to ...
ORGANISM(S): Homo sapiens 
2014-01-01 | E-GEOD-42764 | biostudies-arrayexpress
GenomicsRNAseq_Landscape
RNAseq reads were aligned with STAR 2.5.3a and gene expression was quantified with RSEM 1.3.0
EGAD00010001703 | EGA
GenomicsPRAD-CA_DCCR26_RUNS.2 - samples
This dataset contains fastq files with Whole genome sequencing data for the CPC-Gene Project. Data from each sample was generated using multiple whole genome libraries and sequenced across multiple runs
EGAD00001003761 | EGA
GenomicsDCC_R26.2.PRAD-CNSM-Array
Raw Array data from the PRAD-CA for ICGC DCC Release27
EGAD00010001519 | EGA
Genomics100PG - samples
200PG : WGS Raw Sequence (fastq) : Raw WG sequence data (fastq) in this dataset are from the 124 CPCGene Tumour/Normal Pairs used in the 200PG Study. https://www.ncbi.nlm.nih.gov/pubmed/28068672
EGAD00001001094 | EGA
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