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ProteomicsRole of the E3 Ubiquitin-ligase Hakai in intestinal inflammation and cancer bowel disease
E3 ubiquitin-ligases are important for the cellular protein homeostasis and their deregulation is implicated in cancer. The E3 ubiquitin-ligase Hakai is involved in tumour progression and metastasis, through the regulation of the tumour suppressor E-cadherin. Hakai is overexpressed in colon cancer, ...
ORGANISM(S): Homo sapiens (Human) 
2022-10-25 | PXD029136 | Pride
Intestinal inflammation and cancer bowel disease E3 ubiquitin-ligase hakai Fasn 
ProteomicsHakai is required for stabilization of core components of the m6A mRNA methylation machinery
N6-methyladenosine (m6A) is the most abundant internal modification on mRNA which influences most steps of mRNA metabolism and is involved in several biological functions. The E3 ubiquitin ligase Hakai was previously found in complex with components of the m6A methylation machinery in plants and mam...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2021-04-29 | PXD022294 | Pride
Rna modification M6a Sex determination Hakai 
ProteomicsE3 ubiquitin-ligase Hakai induces LRP4 degradation and regulates Wnt/β-catenin signalling in colorectal cancer cells
The epithelial-mesenchymal transition (EMT) is closely linked to the acquisition of cancer stem cell (CSC) properties, which contribute to treatment resistance and metastasis. This study investigates the role of the E3 ubiquitin-ligase Hakai, the first identified post-translational regulator of E-ca...
ORGANISM(S): Homo sapiens (Human) 
2026-06-22 | PXD069248 | Pride
E3 ubiquitin-ligase hakai  lrp4  wnt/β-catenin pathway  cancer stem cell  colon cancer. 
ProteomicsTwo zinc finger proteins with functions in m6A writing interact with HAKAI
The methyltransferase complex (m6A writer), which catalyzes the deposition of N6-methyladenosine (m6A) in mRNAs, is highly conserved across most eukaryotic organisms, but its components and interactions between them are still far from fully understood. Using in vivo interaction proteomics, two HAKAI...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2022-02-09 | PXD026287 | Pride
Arabidopsis thaliana Zinc finger proteins In vivo crosslinking Hakai N6-methyladenosine (m6a) 
GenomicsTwo novel proteins with opposing m6A writing functions interact with HAKAI [RNA-seq]
Two novel proteins with opposing m6A writing functions interact with HAKAI [RNA-seq]
PRJNA779686 | ENA
Genomicsm6A-RIP-seq of mRNA in yw, Mettl3, Mettl14 and Hakai flies
m6A-RIP-seq of mRNA in yw, Mettl3, Mettl14 and Hakai flies
PRJNA655152 | ENA
GenomicsTwo novel proteins with opposing m6A writing functions interact with HAKAI [meRIP-seq]
Two novel proteins with opposing m6A writing functions interact with HAKAI [meRIP-seq]
PRJNA730562 | ENA
UnknownHakai overexpression effectively induces tumour progression and metastasis in vivo.
Not available
S-EPMC5823865 | biostudies-literature
UnknownHeat Shock Protein 90 Chaperone Regulates the E3 Ubiquitin-Ligase Hakai Protein Stability.
Not available
S-EPMC7017148 | biostudies-literature
UnknownRole of the E3 ubiquitin-ligase Hakai in intestinal inflammation and cancer bowel disease.
Not available
S-EPMC9584894 | biostudies-literature
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