Hall Sarah L SL

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Jarid2 regulates hematopoietic stem cell function by acting with Polycomb Repressive Complex 2

Polycomb Repressive Complex 2 (PRC2) has been shown to play a key role in hematopoietic stem and progenitor cell (HSPC) function. Analyses of mouse mutants harboring deletions of core components have implicated PRC2 in fine-tuning multiple pathways that instruct HSPC behavior, yet how PRC2 is target...

ORGANISM(S): Mus musculus

2015-04-02 | E-GEOD-60808 | biostudies-arrayexpress

Efficacy of JAK/STAT pathway inhibition in murine xenograft models of early T-cell precursor (ETP) acute lymphoblastic leukemia

Early T-cell precursor (ETP) acute lymphoblastic leukemia (ALL) is a recently described subtype of T-ALL characterized by a unique immunophenotype and genomic profile as well as a high rate of induction failure. Frequent mutations in cytokine receptor and JAK/STAT signaling pathways led us to hypoth...

EGAS00001001146 | EGA

DsbA plays a critical and multi-faceted role in the production of secreted virulence factors by Erwinia carotovora

Erwinia carotovora subsp. atroseptica (Eca) is an enterobacterial phytopathogen causing economically-significant soft rot disease. Pathogenesis is mediated by multiple secreted virulence factors, many of which are secreted by the Type II (Out) secretion system. DsbA catalyses the introduction of dis...

ORGANISM(S): Pectobacterium carotovorum

2010-06-20 | E-GEOD-10647 | biostudies-arrayexpress

PCGP ETP ALL SNP6 - samples

PCGP ETP ALL SNP6

EGAD00010000696 | EGA

PCGP ETP WXS1 - samples

DATA FILES FOR PCGP SJETP WXS

EGAD00001001248 | EGA

Real-world outcomes for young adult patients receiving CD19 CAR T-cell therapy.

Not available

S-EPMC12166372 | biostudies-literature

ATD