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UnknownHigh TCL1 levels are a marker of B-cell receptor pathway responsiveness and adverse outcome in chronic lymphocytic leukemia.
Not available
S-EPMC2780304 | biostudies-literature
ProteomicsIntegrated proteomic and phosphoproteomic analysis reveal novel targets and suggest rationale for ibrutinib efficacy in UM-CLL
n order to decipher the underlying mechanisms we aimed to analyze and compare the global phosphoproteome of UM-CLL and M-CLL cells.
ORGANISM(S): Homo sapiens (Human) 
2022-01-14 | PXD016421 | Pride
Cll Proteomics Phosphoproteomics 
ProteomicsStromal cells support the survival of human primary chronic lymphocytic leukemia (CLL) cells
In chronic lymphocytic leukemia (CLL), the tumor cells receive survival support from stromal cells through direct cell contact, soluble factors and extracellular vesicles. The tyrosine protein kinase Lyn, is aberrantly expressed in the malignant and stromal cells in CLL tissue. We therefore studied ...
ORGANISM(S): Homo sapiens (Human) 
2023-01-12 | PXD036932 | Pride
Chronic lymphocytic leukemia Extracellular vesicle Lyn kinase Endosialin 
UnknownEvaluation of a Prognostic Epigenetic Classification System in Chronic Lymphocytic Leukemia Patients.
Not available
S-EPMC8793417 | biostudies-literature
UnknownPrognostic impact of prevalent chronic lymphocytic leukemia stereotyped subsets: analysis within prospective clinical trials of the German CLL Study Group (GCLLSG).
Not available
S-EPMC7604575 | biostudies-literature
UnknownPhase I/II trial of capecitabine and oxaliplatin in combination with bevacizumab and imatinib in patients with metastatic colorectal cancer: AIO KRK 0205.
Not available
S-EPMC3776974 | biostudies-literature
ProteomicsSecretome of LYN deficient HS-5 stroma cells
LYN kinase is a tyrosine kinase, that regulates cellular homeostasis in a context specific manner. Our group could show, that its expression in the leukemic microenvironment of chronic lymphocytic leukemia contributes to disease progression (Nguyen PH et al.; Cancer Cell; 2016). To analyze the effec...
ORGANISM(S): Homo sapiens (Human) 
2023-05-10 | PXD028855 | Pride
Lyn kinase Hs-5 Stroma Bmsc Secretome Multi-omics 
UnknownMARCKS affects cell motility and response to BTK inhibitors in CLL.
Not available
S-EPMC8377477 | biostudies-literature
UnknownGuidelines for the diagnosis and treatment of chronic lymphocytic leukemia: a report from the International Workshop on Chronic Lymphocytic Leukemia updating the National Cancer Institute-Working Group 1996 guidelines.
Not available
S-EPMC2972576 | biostudies-literature
UnknownCOVID-19 in patients with hematologic malignancy.
Not available
S-EPMC9098396 | biostudies-literature
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