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ProteomicsQuantifying extracellular matrix turnover in human lung scaffold cultures
Tissue engeneering using biological scaffolds are a promising technique for solving the shortage of donor organs for patients suffering of end stage organ faliure. We introduced stable isotope labeling with amino acids in a tissue culture setting, which enabeled us to distinguish between the biologi...
ORGANISM(S): Homo sapiens (Human) 
2018-04-09 | PXD007995 | Pride
Human Ecm Lung Silac 
ProteomicsAlveolar epithelial cells are competent producers of interstitial extracellular matrix with disease relevant plasticity in a human in vitro 3D model
The structure of alveoli is critical for proper lung function, the extracellular matrix (ECM) that forms these delicate structures need to be maintained throughout life, when this fails, patients suffer from conditions such as emphysema or lung fibrosis. The alveolar walls are lined by alveolar epit...
ORGANISM(S): Homo sapiens (Human) 
2023-06-29 | PXD034531 | Pride
Human Ecm Ipf Copd Lung Remodeling Alveolar epithelium 
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