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TranscriptomicsMicroarray profiling reveals Integrated Stress Response is activated by Halofuginone in mammary epithelial cells
The small molecule Halofuginone (HF) is a potent regulator of extracellular matrix (ECM ) gene expression and is unique in its therapeutic potential. While the basis for HF effects is unknown, inhibition of TGFb signaling and activation of the AAR have been linked to HF transcriptional control of a...
ORGANISM(S): Mus musculus 
2011-10-17 | E-GEOD-30667 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse T cells treated with halofuginone to investigate regulation of Y cell gene expression by Halofuginone (HF)
T cell differentiation to the Th17 effector subset requires stimulation through the T cell and co-stimulatory receptors, together with cytokine stimulation by TGFb and IL-6. The small molecule halofuginone (HF) inhibits Th17 cell development and induces a pattern of stress-regulated gene expression ...
ORGANISM(S): Mus musculus 
2009-04-19 | E-GEOD-15624 | biostudies-arrayexpress
TranscriptomicsTranscriptional responses of wild-type and Gcn2-/- Th17 cells to halofuginone and rapamycin
This study was designed to evaluate similarities and differences between transcriptional responses of developing Th17 cells to the prolyl-tRNA synthetase inhibitor, halofuginone, and the mTOR inhibitor, rapamycin. Further comparisons between wild-type and Gcn2-/- Th17 cells allow for investigation i...
ORGANISM(S): Mus musculus 
2014-05-29 | E-GEOD-47478 | biostudies-arrayexpress
ProteomicsProteome expression changes upon Halofuginone treatment
NHCF-V primary cardiac fibroblasts where treated for 24 hours with either 1) 100nM Halofuginone (TMT labels 126 and 129L) 2) 300nM Halofuginone (TMT labels 127L and 129H) 3) 300 nM Halofuginone + 4 mM L-Pro (TMT labels 127H and 130L) 4) DMSO (TMT labels 128H and 131)
ORGANISM(S): Homo sapiens (Human) 
2017-05-16 | PXD005679 | Pride
Primary cardiac fibroblasts Human Halofuginone 
GenomicsHalofuginone is a potent inhibitor of SARS-CoV-2 Infection and Replication [Exp1]
Halofuginone is a potent inhibitor of SARS-CoV-2 Infection and Replication [Exp1]
PRJNA659915 | ENA
GenomicsHalofuginone is a potent inhibitor of SARS-CoV-2 Infection and Replication [Exp3]
Halofuginone is a potent inhibitor of SARS-CoV-2 Infection and Replication [Exp3]
PRJNA700843 | ENA
GenomicsHalofuginone is a potent inhibitor of SARS-CoV-2 Infection and Replication [Exp2]
Halofuginone is a potent inhibitor of SARS-CoV-2 Infection and Replication [Exp2]
PRJNA659924 | ENA
UnknownTranscriptome profile of halofuginone resistant and sensitive strains of Eimeria tenella.
Not available
S-EPMC10098198 | biostudies-literature
GenomicsTranscriptome profiling of the liver and white adipose tissue of DIO mice treated with halofuginone.
Transcriptome profiling of the liver and white adipose tissue of DIO mice treated with halofuginone.
PRJNA1144115 | ENA
UnknownHalofuginone, a promising drug for treatment of pulmonary hypertension.
Not available
S-EPMC9792225 | biostudies-literature
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