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UnknownStandardised Sonneratia apetala Buch.-Ham. fruit extract inhibits human neutrophil elastase and attenuates elastase-induced lung injury in mice.
Not available
S-EPMC9768866 | biostudies-literature
TranscriptomicsStress-related gene expression in HK-2 cells exposed to pH 7.4, 7.0 or 6.7
Chronic metabolic acidosis occurs commonly in patients with diseased kidneys and is linked with progression to renal failure. As renal function declines there is loss of nephron mass and adaptive proximal tubular hypertrophy and hypermetabolism. We have previously demonstrated in an in vitro model o...
ORGANISM(S): Homo sapiens 
2012-09-11 | E-GEOD-23995 | biostudies-arrayexpress
TranscriptomicsAnalysis of wildtype and Xbp1-deficient hematopoietic progenitor cell transcriptomes
Purpose: The goals of this study are to assess the transcriptional networks governed by the transcription factor XBP1 in lineage-uncommitted myeloid progenitors and in eosinophil-committed myeloid progenitors. Methods: mRNA profiles of FACS-purified granulocyte-macrophage progenitors (GMPs) from X...
ORGANISM(S): Mus musculus 
2015-07-06 | E-GEOD-65753 | biostudies-arrayexpress
TranscriptomicsMolecular targets of doxazosin in human prostatic stromal cells
BACKGROUND: We used cDNA microarray analysis to obtain insights into the mechanisms of action of doxazosin, an alpha(1)-adrenergic receptor antagonist used to treat benign prostatic hyperplasia (BPH). METHODS: Hierarchical clustering analysis and significance analysis of microarray (SAM) were perfor...
ORGANISM(S): Homo sapiens 
2006-01-10 | E-GEOD-4010 | biostudies-arrayexpress
ProteomicsS-Adenosylmethionine Negatively Regulates the Mitochondrial Respiratory Chain Repressor MCJ in the Liver
MCJ (Methylation-Controlled J protein), an endogenous repressor of the mitochondrial respiratory chain, is upregulated in multiple liver diseases but little is known about how it is regulated. S-adenosylmethionine (SAMe), the biological methyl donor, is frequently depleted in chronic liver diseases....
ORGANISM(S): Mus Musculus 
PXD042309 | panorama
TranscriptomicscDNA microarray profiles of canine mammary tumour cell lines reveal deregulated pathways pertaining to their phenotype
Mammary cancer is the most common type of cancer in female dogs with a lifetime risk of over 24% when dogs are not spayed. The elucidation of the complete canine genome opens new areas for development of cancer therapies. These should be tested first by in vitro models such as cell lines. However, t...
ORGANISM(S): Canis lupus familiaris 
2007-09-01 | E-GEOD-7659 | biostudies-arrayexpress
TranscriptomicsRNA-seq of three Spodoptera frugiperda tissues (Midgut, Fat body, Hemocytes), at 2 time-points (8h and 15h) after infestation by entomopathogenic nematodes Steinernema carpocapsae/Xenorhabdus nematophila
Nematodes such as Steinernema carpocapsae are used as organic pesticides because of their ability to prey on live insects. They do so thanks to their symbiotic bacteria, that they release within the hemocoel of insects. In this study we wanted to study how Spodoptera frugiperda, a Lepidoptera pest o...
ORGANISM(S): Spodoptera frugiperda 
2019-12-03 | E-MTAB-7976 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of doxazosin response, an alpha(1)-adrenergic receptor antagonist used to treat benign prostatic hyperplasia (BPH)
BACKGROUND: We used cDNA microarray analysis to obtain insights into the mechanisms of action of doxazosin, an alpha(1)-adrenergic receptor antagonist used to treat benign prostatic hyperplasia (BPH). METHODS: Hierarchical clustering analysis and significance analysis of microarray (SAM) were perfor...
ORGANISM(S): Homo sapiens 
2005-11-07 | E-SMDB-2934 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human cell lines from Hay Wells Syndrome-Derived TAp63alphaQ540L mutant rveals impaired transcriptional and cell growth regulatory activity
p63 mutations have been associated with several human hereditary disorders characterized by ectodermal dysplasia such as EEC syndrome, ADULT syndrome and AEC syndrome . The location and functional effects of the mutations that underlie these syndromes reveal a striking genotype-phenotype correlati...
ORGANISM(S): Homo sapiens 
2008-06-16 | E-GEOD-8646 | biostudies-arrayexpress
TranscriptomicsIdentification of differentially expressed genes in fibroblasts derived from patients with Dupuytren's Contracture
Dupuytren's contracture (DC) is the most common inherited connective tissue disease of humans and is hypothesized to be associated with aberrant wound healing of the palmar fascia. Fibroblasts and myofibroblasts are believed to play an important role in the genesis of DC and the fibroproliferation a...
ORGANISM(S): Homo sapiens 
2010-04-16 | E-GEOD-21221 | biostudies-arrayexpress
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