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ProteomicsSimultaneous chemical proteomics of Nuclear, mitochondira and ER
The endoplasmic reticulum (ER) is an organelle that performs a variety of essential cellular functions via interactions with other organelles. Despite its important role, chemical tools for profiling the composition and dynamics of ER proteins remain very limited because of the labile nature of thes...
ORGANISM(S): Homo sapiens (Human) 
2019-01-07 | PXD011501 | Pride
Hela cell Chemical proteomics Mitochondria Er Nuclear 
ProteomicsProteome labeled by a cuprous ion-responsive protein labeling reagent in the ATP7A WT and ATP7A KO living cells
We have developed a new molecular probe called CuR. This probe is selectively activated by labile Cu(I), hence enabling labeling of the proteins in Cu(I)-rich cellular environments. We applied CuR to ATP7A-WT and ATP7A-KO cells that were pretreated with or without Cu(gtsm). Next, we enriched the lab...
ORGANISM(S): Homo Sapiens (human) 
2025-01-05 | PXD048267 | JPOST Repository
ProteomicsTMT-based quantitative MS analysis of proteome labeled by NO-responsive reaction with NOAR-2
RAW264.7 cells were treated by LPS and IFN-gamma for 20 h. The LPS/IFN treated or nontreated cells were labeled by NOAR-2 for 1 h. Cells were lysed by NP-40 buffer. Labeled proteins were purified by immunopecipitation using anti-fluorescein, then digested by trypsin. Digested peptides were labeled ...
ORGANISM(S): Mus Musculus (mouse) 
2020-01-12 | PXD012310 | JPOST Repository
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