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TranscriptomicsIdentification of direct T-box target genes in the developing zebrafish mesoderm
The zebrafish genes spadetail (spt) and no tail (ntl) encode T-box transcription factors that are important for early mesoderm development. Although much has been done to characterize these genes, the identity and location of target regulatory elements remain largely unknown. Here, we survey the gen...
ORGANISM(S): Danio rerio 
2010-05-19 | E-GEOD-12857 | biostudies-arrayexpress
TranscriptomicsTranscriptomic profiles of zebrafish embryos exposed to silver (nanoparticles, bulk and ions) using HT-SuperSAGE in a Illumina GA2 platform
Silver nanoparticles cause toxicity in exposed organisms and are an environmental health concern. The mechanisms of silver nanoparticle toxicity, however, remain unclear. We examined the effects of exposure to silver in nano-, bulk- and ionic forms on zebrafish embryos (Danio rerio) using a Next Gen...
ORGANISM(S): Danio rerio 
2013-06-17 | E-GEOD-38125 | biostudies-arrayexpress
TranscriptomicsRNA-Seq of zebrafish embryos (96hpf) treated with different concentrations of Triiodothyronine (T3) below acute toxicity levels against untreated control groups
The aim of this sequencing experiment was to screen for ecotoxicogenomic fingerprints for endocrine disrupting chemicals affecting the thyroid system in zebrafish (Danio rerio) embryos as aquatic vertebrate model and alternative to animal testing. Triiodothyronine (T3, CAS: 6893-02-3) was tested as ...
ORGANISM(S): Danio rerio 
2020-09-30 | E-MTAB-9056 | biostudies-arrayexpress
TranscriptomicsTranscriptomic profiling of clobetasol propionate-induced immunosuppression in challenged zebrafish embryos
The aim of this experiment was to develop an approach for the assessment of immunotoxicity in zebrafish embryos (Danio rerio) using transcriptomic profiling. Clobetasol propionate, a highly potent synthetic corticosteroid, which is known to have immunosuppressive effects on vertebrates including zeb...
ORGANISM(S): Danio rerio 
2022-02-25 | E-MTAB-11092 | biostudies-arrayexpress
TranscriptomicsRNA-Seq of zebrafish embryos (96hpf) treated with different concentrations of 6-Propyl-2-thiouracil (6-PTU) below acute toxicity levels against untreated control groups
Endocrine disruption can trigger far-reaching effects on environmental populations, justifying a refusal of market approval for chemicals with ED properties. Ecotoxicogenomic screening was performed to identify molecular fingerprints for endocrine disrupting chemicals affecting the thyroid system in...
ORGANISM(S): Danio rerio 
2020-09-30 | E-MTAB-9054 | biostudies-arrayexpress
TranscriptomicsStructurally distinct polycyclic aromatic hydrocarbons induce differential transcriptional responses in developing zebrafish
Polycyclic aromatic hydrocarbons (PAHs) are ubiquitous in the environment as components of fossil fuels and by-products of combustion. These multi-ring chemicals differentially activate the Aryl Hydrocarbon Receptor (AHR) in a structurally-dependent manner, and induce toxicity via both AHR-dependent...
ORGANISM(S): Danio rerio 
2013-05-15 | E-GEOD-44130 | biostudies-arrayexpress
TranscriptomicsChromatin immunoprecipitation of mouse hematopoietic cell lines and tissue-types to identify histone modification and transcription factor binding sites
Histone modification and transcription factor ChIP-chip in hematopoietic cell lines and tissue-types
ORGANISM(S): Mus musculus 
2009-01-28 | E-TABM-431 | biostudies-arrayexpress
TranscriptomicsSperm but not oocyte DNA methylome is inherited by zebrafish early embyros
5-methylcytosine is a major epigenetic modification sometimes called "the fifth nucleotide". However, our knowledge of how offspring inherit the DNA methylome from parents is limited. We generated nine single-base resolution DNA methylomes including zebrafish gametes and early embryos. The...
ORGANISM(S): Danio rerio 
2013-05-20 | E-GEOD-44075 | biostudies-arrayexpress
TranscriptomicsExercise promotes growth and vascularization of fast skeletal muscle by activating myogenic and angiogenic transcriptional programs in adult zebrafish
The adult skeletal muscle is a plastic tissue with a remarkable ability to adapt to different levels of activity by altering its excitability, its contractile and metabolic phenotype and its mass. Knowledge on the mechanisms responsible for muscle mass comes primarily from models of muscle inactivit...
ORGANISM(S): Danio rerio 
2014-12-23 | E-GEOD-58929 | biostudies-arrayexpress
TranscriptomicsRNA-seq of zebrafish embryos exposed to different sublethal concentrations of ethinylestradiol for 96 hours against non-treated control groups
Endocrine disruption (ED) can trigger far-reaching effects on environmental populations, justifying a refusal of market approval for chemicals with ED properties. For the assessment of ED effects on development and reproduction, regulatory decisions mostly rely on apical endpoints from in vivo testi...
ORGANISM(S): Danio rerio 
2023-05-10 | E-MTAB-12221 | biostudies-arrayexpress
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