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MetabolomicsHost specific sphingomyelin is critical for replication of diverse RNA viruses
Lipids and lipid metabolism play an important role in RNA virus replication, which typically occurs on host cell endomembrane structures in the cytoplasm through mechanisms that are not yet fully identified. We conducted genome-scale CRISPR screening and identified sphingomyelin synthase 1 (SMS1; en...
2026-10-29 | MTBLS11308 | MetaboLights
ProteomicsToxicokinetics of arenobufagin and its cardiotoxicity mechanism exploration based on lipidomics and proteomics approaches in rats
In this study, the hearts used for proteomics analysis were obtained from rats randomly divided into three groups (6 rats in each group): a control group (a mixture of propanediol and sodium chloride solution), a low-dose ArBu group (ArBu suspension 60 mg/kg) and a high-dose ArBu group (ArBu suspens...
ORGANISM(S): Rattus Norvegicus 
2021-09-17 | PXD028622 |
ProteomicsProteome analysis reveals novel serum biomarkers for Henoch-Schönlein purpura in Chinese children
We performed proteomic profiling on serum samples from HSP patients and healthy children using an approach combining magnetic bead-based weak cation exchange and matrix-assisted laser desorption ionization-time of flight mass spectrometry. We next performed liquid chromatography-electrospray ionizat...
ORGANISM(S): Homo Sapiens 
2022-04-02 | PXD032897 |
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