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TranscriptomicsExpression data from kidneys of rats with and without cisplatin treatment
We investigated an acute kidney injury (AKI) model in rats induced by cisplatin (Cp) administration. The cisplatin is widely used since its biochemical and histopathological characteristics are representative of drug-induced AKI in humans. Male Wistar rats were dosed once ip with 0, 1 and 3 mg/kg ...
ORGANISM(S): Rattus norvegicus 
2016-08-23 | E-GEOD-85957 | biostudies-arrayexpress
GenomicsThe characteristics of genome-wide DNA methylation in naM-CM-/ve CD4+ T cells of patients with psoriasis and atopic dermatitis
Psoriasis and atopic dermatitis (AD) are characterized by polarized CD4+ T cell responses. During the polarization of naM-CM-/ve CD4+ T cells, DNA methylation plays an important role in the regulation of gene transcription. In this study, we profiled the genome-wide DNA methylation status of naM-CM-...
ORGANISM(S): Homo sapiens 
2012-03-17 | E-GEOD-35582 | biostudies-arrayexpress
UnknownOC-STAMP promotes osteoclast fusion for pathogenic bone resorption in periodontitis via up-regulation of permissive fusogen CD9.
Not available
S-EPMC5998976 | biostudies-literature
TranscriptomicsmiR-222 is necessary for exercise-induced cardiac growth and protects against pathological cardiac remodeling.
miR-222 overexpression leads to promotion of proliferation and hypertrophy and inhibition of apoptosis in in primary neonatal rat ventricular cardiomyocytes (NRVMs). Isolated primary neonatal rat ventricular cardiomyocytes were plated in 6 cm BD Primaria tissue culture dishes. Transfection of microR...
ORGANISM(S): Rattus norvegicus 
2016-03-03 | E-GEOD-59641 | biostudies-arrayexpress
UnknownFast and sensitive differential diagnosis of pseudorabies virus-infected versus pseudorabies virus-vaccinated swine using CRISPR-Cas12a.
Not available
S-EPMC10783010 | biostudies-literature
TranscriptomicsThe Exoribonuclease Nibbler Controls 3' End Processing of MicroRNAs in Drosophila
MicroRNAs (miRNAs) are endogenous noncoding small RNAs with important roles in many biological pathways; their generation and activity are under precise regulation. Emerging evidence suggests that miRNA pathways are precisely modulated with controls at the level of transcription, processing, and sta...
ORGANISM(S): Drosophila melanogaster 
2011-11-17 | E-GEOD-31689 | biostudies-arrayexpress
TranscriptomicsFunctional implications of miR-19 in the migration of newborn neurons in the adult brain
Gene expression change after overexpression and knockdown of miR-19 in rat adult hippocampal NPCs.
ORGANISM(S): Rattus norvegicus 
2019-02-13 | E-MTAB-4807 | biostudies-arrayexpress
TranscriptomicscDNA microarray analysis of miR-1 transfected HeLa and NPC-TW01 cells
To investigate the mechanisms of miR-1 inducing apoptosis, we performed cDNA expression microarray analysis to identify the candidate miR-1 regulating genes that are involved in apoptosis. NPC-TW01 cells were transfected with miR-1 or miR-negative control for 40 hours, their total RNA were isolated ...
ORGANISM(S): Homo sapiens 
2011-04-13 | E-GEOD-28522 | biostudies-arrayexpress
TranscriptomicsDevelopmental decoupling of alternative phenotypes: insights from the transcriptomes of horn-polyphenic beetles
Developmental mechanisms play an important role in determining the costs, limits, and evolutionary consequences of phenotypic plasticity. One issue central to these claims is the metaphor of developmental “decoupling,” where alternate morphs result from evolutionarily independent developmental path...
ORGANISM(S): Onthophagus taurus 
2010-09-15 | E-GEOD-23425 | biostudies-arrayexpress
TranscriptomicsDicer Partner Proteins Tune the Length of Mature miRNAs in Flies and Mammals
Drosophila Dicer-1 produces microRNAs (miRNAs) from pre-miRNA, whereas Dicer-2 generates small interfering RNAs (siRNAs) from long dsRNA. loquacious (loqs) encodes three Dicer partner proteins, Loqs-PA, Loqs-PB, and, Loqs-PD, generated by alternative splicing. To understand the function of each Loqs...
ORGANISM(S): Mus musculus 
2012-12-07 | E-GEOD-37443 | biostudies-arrayexpress
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