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Tripeptidyl peptidase II (TPPII) degrades N-terminal tripeptides from proteins and peptides. Studies in both human and mice have shown that TPPII deficiency is linked to cellular immune-senescence, lifespan regulation, and the aging process. However, the mechanism of how TPPII participates in these ...
ORGANISM(S): Homo sapiens (Human) 
2022-05-31 | PXD033808 | Pride
Senescent cells exhibit a reduced response to intrinsic and extrinsic stimuli. This reduction could be explained by disrupted nuclear transmission of signals. However, this hypothesis required more evidence to complete as a new modality of cellular senescence. Proteomic analysis of the cytoplasmic a...
ORGANISM(S): Homo sapiens (Human) 
2021-06-18 | PXD025618 | Pride
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