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MetabolomicsMethionine Intervention Induces PD-L1 Expression to Enhance the Immune Checkpoint Therapy Response in MTAP-deleted Osteosarcoma
Osteosarcoma (OS), a malignant bone tumor with limited treatment options, exhibits low sensitivity to immune checkpoint therapy (ICT). Through genomics and transcriptomics analyses, we have identified a subgroup of OS with methylthioadenosine phosphorylase (MTAP) deletion, which contributes to ICT r...
2026-06-09 | MTBLS11985 | MetaboLights
ProteomicsNoncanonical amino acid-aided synthesis of anti-PD-L1 bispecific nanobody for colon cancer immunotherapy
Colorectal cancer (CRC) is the second leading cause of cancer-related mortality, and the incidence of early-onset colon cancer has been increasing globally in recent years. The development of immunotherapies for colon cancer is critical for providing new treatment strategies to combat drug resistanc...
ORGANISM(S): Escherichia coli 
2026-01-12 | PXD069482 | Pride
Bispecific antibody Maldi-tof Noncanonical amino acid 
ProteomicseIF3 subunit-specific mRNA selectivity profiling reveals eIF3k as a cancer-relevant regulator of ribosome content
eIF3, whose subunits are frequently overexpressed in cancer, regulates mRNA translation from initiation to termination, but mRNAeIF3, whose subunits are frequently overexpressed in cancer, regulates mRNA translation from initiation to termination, but mRNA-selective functions of individual subunits ...
ORGANISM(S): Homo sapiens (Human) 
2023-03-14 | PXD034084 | Pride
Eif3 
ProteomicsProteomic analysis of periodontal tissue reveals β-guanidinopropionic acid (β-GPA) mediated inhibition of the TLR4 pathway in a mouse model of hyperlipidemic periodontitis.
This project aims to elucidate the molecular mechanisms by which the gut microbial metabolite β-guanidinopropionic acid (β-GPA) alleviates hyperlipidemic periodontitis (HPD). We performed Tandem Mass Tag (TMT) based quantitative proteomic analysis on periodontal tissues from HPD model mice versus th...
ORGANISM(S): Mus Musculus 
2025-10-13 | PXD069376 |
UnknownRobust estimation of bacterial cell count from optical density.
Not available
S-EPMC7499192 | biostudies-literature
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