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TranscriptomicsRNASeq of Plasmodium falciparum 3D7 WT compared to MSP2 KO
Plasmodium falciparum malaria remains a global health challenge and causes a significant number of deaths in tropical and subtropical countries annually. Merozoite surface proteins, located of the surface of the invasive stage of the parasite, are targets of immunity and have been explored as vaccin...
ORGANISM(S): Plasmodium falciparum 
2026-01-01 | E-MTAB-15427 | biostudies-arrayexpress
TranscriptomicsEstrogen-modulated gene expression in c-kit+ stem cells and CD44+ stromal cells
The recent interest in the role of bone marrow derived endothelial progenitor cells in the benefits of estrogen on cardiovascular health brought us to evaluate if estrogen could affect cardiac repair more broadly by regulating biological processes involved in the functional organization of the bone ...
ORGANISM(S): Mus musculus 
2008-12-10 | E-GEOD-9098 | biostudies-arrayexpress
Genomics37a30206-29b3-47a0-90c4-eee326fe5b8b - samples
Genotype calls for 83 Aboriginal Australian genomes split by chromosomes. In short, genotypes were called individually with samtools. They were subsequently filtered with thresholds related to sequencing depth, location of variants, sequencing error, and strand bias. Once combined, the genotypes wer...
EGAD00001004155 | EGA
TranscriptomicsMolecular regulation of enhanced muscle mass in developing Blond Aquitaine foetuses compared to Charolais
Background : The Blonde Aquitaine (BA) is a French beef breed with enhanced muscularity of unknown genetic origin. Targeted sequencing has shown that the BA is not a carrier of any of the bovine MSTN mutations. At the protein level the BA shows a transition to a faster muscle isoform phenotype with ...
ORGANISM(S): Bos taurus 
2015-08-01 | E-GEOD-60844 | biostudies-arrayexpress
TranscriptomicsmiR-155 KO in human dendritic cells
In response to inflammatory stimulation, dendritic cells (DCs) have a remarkable pattern of differentiation (maturation) that exhibits specific mechanisms to control immunity. Here, we show that in response to Lipopolysaccharides (LPS), several microRNAs (miRNAs) are regulated in human monocyte-deri...
ORGANISM(S): Homo sapiens 
2009-03-04 | E-GEOD-13296 | biostudies-arrayexpress
TranscriptomicsRegulatory role of multinucleated giant cells derived from placental CD14+ macrophages: Pathophysiological implications
The role of placental macrophages is largely ignored in the success of pregnancy. We found that CD14+ macrophages purified from at-term placentas spontaneously matured into multinucleated giant cells (MGCs). MGCs lost the expression of CD14 and co-inhibitory molecules, such as Programmed cell Death-...
ORGANISM(S): Homo sapiens 
2014-01-07 | E-GEOD-38747 | biostudies-arrayexpress
TranscriptomicsAnalysis of the gene expression pattern of bovine blastocysts at three stages of development
Blastocyst formation is a primordial event of pre-implantation development since it is required for pregnancy establishment and progression. The blastocyst plays a pivotal role because it is the stage at which the embryo is transferred and starts coordinated cross-talks with the mother. It is also t...
ORGANISM(S): Bos taurus 
2011-02-17 | E-GEOD-25606 | biostudies-arrayexpress
TranscriptomicsRoutine use of microarray-based gene expression profiling to identify patients with low cytogenetic risk acute myeloid leukemia: accurate results can be obtained even with suboptimal samples (training samples)
Background: Gene expression profiling has shown its ability to identify with high accuracy low cytogenetic risk acute myeloid leukemia such as acute promyelocytic leukemia and leukemias with t(8;21) or inv(16). The aim of this gene expression profiling study was to evaluate to what extent suboptimal...
ORGANISM(S): Homo sapiens 
2011-12-21 | E-GEOD-34577 | biostudies-arrayexpress
TranscriptomicsmRNA differential expression analysis in a human ex vivo model of chronic wounds
To study the fibroblast to myofibroblast differentiation in a normal or pathological situation, NHDF (Normal human dermal fibroblast) obtained from two different healthy donors (donors A and B) were either left untreated (T-E-) either treated with TGF-beta alone (T+E-), or with exudate from chronic ...
ORGANISM(S): Homo sapiens 
2015-12-16 | E-GEOD-49159 | biostudies-arrayexpress
TranscriptomicsCoverage-Immuno
COVERAGE-Immuno is a project that aims to perform in-depth, repeated evaluation of immunological markers and RNA data in COVID-19 patients who are being treated at home, to learn more about the disease. The project is embedded in an existing randomised clinical trial, called COVERAGE, that is evalua...
ORGANISM(S): Homo sapiens 
2026-09-01 | E-MTAB-15066 | biostudies-arrayexpress
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