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TranscriptomicsComparative analysis of regulatory elements between Escherichia coli and Klebsiella pneumoniae by genome-wide transcription start site profiling [TSS-Seq]
We report the application of single-molecule-based sequencing technology for high-throughput profiling of transcription start sites for two enterobacteria: Escherichia coli and Klebsiella pneumoniae.By obtaining over fourteen billion bases of sequence from 5' RACE (rapid amplification of cDNA ends) ...
ORGANISM(S): Escherichia coli K-12 
2012-07-30 | E-GEOD-35821 | biostudies-arrayexpress
TranscriptomicsGene expression profiles of spontaneous metastasis in a K-ras/p53 mutant mouse model
The biologic basis for NSCLC metastasis is not well understood. Here we addressed this deficiency by transcriptionally profiling tumors from a genetic mouse model of human lung adenocarcinoma that develops metastatic disease owing to the expression of K-rasG12D and p53R172H. We identified 2,209 gene...
ORGANISM(S): Mus musculus 
2009-04-14 | E-GEOD-14449 | biostudies-arrayexpress
TranscriptomicsmRNA-Seq of Daphnia magna exposed to acesulfame K and its photodegradation products against untreated control groups
The experiment investigates how the artificial sweetener acesulfame K and its photodegradation products affect the gene expression in the freshwater invertebrate Daphnia magna. Juvenile D. magna were subjected to an acute immobilization test (OECD Guideline 202) followed by RNA extraction and transc...
ORGANISM(S): Daphnia magna 
2026-09-25 | E-MTAB-17689 | biostudies-arrayexpress
TranscriptomicsmRNA-Seq of Danio rerio exposed to acesulfame K and its photodegradation products against untreated control groups
The experiment investigates how the artificial sweetener acesulfame K and its photodegradation products affect the gene expression in the teleost fish Danio rerio. The main test including transcriptomics, was conducted with 10 µg/L and 100 mg/L as test concentrations. Pooled animals from each exposu...
ORGANISM(S): Danio rerio 
2026-09-25 | E-MTAB-17688 | biostudies-arrayexpress
TranscriptomicsDefective K-Ras Oncoproteins Initiate Cancer In Vivo and Evolve to Overcome Impaired Effector Binding
The oncogenic proteins expressed in human cancer cells are exceedingly difficult targets for drug discovery due to intrinsic properties of the Ras GTPase switch. As a result, recent efforts have largely focused on inhibiting Ras-regulated kinase effector cascades, particularly the Raf/MEK/ERK and PI...
ORGANISM(S): Mus musculus 
2011-09-30 | E-GEOD-28687 | biostudies-arrayexpress
TranscriptomicsDown-regulation of Interferon signature in systemic lupus erythematosus patients by active immunization with Interferon alpha-Kinoid
We performed a phase I/II, randomized, double-blind, placebo-controlled dose-escalation study to examine the safety, immunogenicity, and biological effects of active immunization with interferon alpha-Kinoid (IFN-K) in systemic lupus erythematosus (SLE) patients. Women 18-50 years of age with mild t...
ORGANISM(S): Homo sapiens 
2012-11-01 | E-GEOD-39088 | biostudies-arrayexpress
UnknownAn additional k-means clustering step improves the biological features of WGCNA gene co-expression networks.
Not available
S-EPMC5389000 | biostudies-literature
UnknownStructure, function, and ion-binding properties of a K+ channel stabilized in the 2,4-ion-bound configuration.
Not available
S-EPMC6708363 | biostudies-literature
TranscriptomicsTranscriptomic differences between E. coli B REL606 and K-12 MG1655
Transcriptome profiles were analyzed using the samples taken at the exponential and stationary phases during the cultivation of REL606 and MG1655 in LB medium. At the exponential growth phase, most highly expressed genes of B were those for replication, translation, or nucleotide transport and metab...
ORGANISM(S): Escherichia coli 
2010-05-22 | E-GEOD-13011 | biostudies-arrayexpress
ProteomicsLC-MSMS of primary AML class I immunopeptidome (mTECs+MPCs k-mer depletion approach)
The development of therapeutic anticancer vaccines calls for the identification of tumor-specific antigens (TSAs). Though a combination of four cutting-edge proteogenomic approaches, we performed a deep exploration of the MHC-I presented peptides (MAPs) of 19 acute myeloid leukemia (AML) patients an...
ORGANISM(S): Homo sapiens (Human) 
2021-03-19 | PXD018539 | Pride
Aml Lc-msms Immunopeptidome Mhc class i 
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