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UnknownAn estimation of global genetic prevalence of PLA2G6-associated neurodegeneration.
Not available
S-EPMC11489993 | biostudies-literature
GenomicsNext-Generation Sequencing of sgRNA spacer sequences from a CRISPRi library screen of the Salmonella enterica serovar Typhimurium 14028s genome in response to repeated monoclonal IgA treatment
For this study, we implemented the anti-lipopolysaccharide monoclonal IgA Sal4 in a genome-wide CRISPR interference (CRISPRi) screen to identify genes that modulate the extent of agglutination of Salmonella enterica serovar Typhimurium (STm) in response to antibody exposure. We leveraged our recentl...
ORGANISM(S): Salmonella enterica subsp. enterica serovar Typhimurium 
2025-02-16 | E-MTAB-14834 | biostudies-arrayexpress
TranscriptomicsA Parallel Study of mRNA and MicroRNA Profiling of Peripheral Blood in Young Adult Women
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2013-08-13 | E-GEOD-30205 | biostudies-arrayexpress
TranscriptomicsGene Expression Data from Prefrontal Cortex and Nucleus Accumbens from Inbred Strains of Mice
Catechol-O-methyltransferase (COMT) is an ubiquitously expressed enzyme that maintains basic biologic functions by inactivating catechol substrates. In humans, polymorphic variance at the COMT locus has been associated with modulation of pain sensitivity (Andersen & Skorpen, 2009) and risk for devel...
ORGANISM(S): Mus musculus 
2010-02-23 | E-GEOD-20160 | biostudies-arrayexpress
TranscriptomicsRibosome profiling of HeLa cells infected with Enterovirus coxsackiepol (strain CVA-13/Flores)
Ribosome profiling of enterovirus infected cells was used to investigate expression of the virus polyprotein and upstream open reading frames. Samples were either pretreated with initiation inhibitor lactimidomycin (LTM) to cause ribosomes to accumulate at initiation sites, or were flash frozen with...
ORGANISM(S): Homo sapiens 
2025-11-26 | E-MTAB-14994 | biostudies-arrayexpress
TranscriptomicsRNA-seq of MYC-Low and MYC-High FC-MYC Cells Following SUMOylation Inhibition with SAEi ML-792
The synthetic lethal relationship between MYC and SAE2 has been previously described in FC-MYC cells using RNAi (Littler et al., 2019). Building on this work, we conducted transcriptomic analysis on MYC-low and MYC-high cells following inhibition of SUMOylation with the SAE1/2 inhibitor, ML-792 (SAE...
ORGANISM(S): Homo sapiens 
2025-04-01 | E-MTAB-14654 | biostudies-arrayexpress
TranscriptomicsAre Non-animal Systemic Safety Assessments Protective: A Toolbox and Workflow
High throughput transcriptomics using the TempO-Seq (TM) platform for dose response modelling of 3 different cell lines treated with multiple compounds as part of a study to generate a toolbox and workflow for non-animal safety assessments. The data generated here was produced as one part of a toolb...
ORGANISM(S): Homo sapiens 
2025-09-15 | E-MTAB-15258 | biostudies-arrayexpress
TranscriptomicsEctoderm specification of H1 human embryonic stem cells
In recent years, several studies have shed light into the processes that regulate epidermal specification and homeostasis. We previously showed that a broad-spectrum γ–secretase inhibitor DAPT promoted early keratinocyte specification in human embryonic stem cells triggered to undergo ectoderm speci...
ORGANISM(S): Homo sapiens 
2015-03-05 | E-GEOD-66506 | biostudies-arrayexpress
TranscriptomicsThe Nicotinic alpha6 Subunit Gene Determines Variability in Chronic Pain Sensitivity and Nicotine Anti- allodynia via Cross-inhibition of P2X2/3 Receptors.
We used microarray-based expression genomics in 25 inbred mouse strains to identify dorsal root ganglion (DRG)-expressed genetic contributors to mechanical allodynia a prominent symptom of chronic pain. Expression genetics identifies a role for the Chrna6 (alpha 6-nicotinic receptor) gene in pain in...
ORGANISM(S): Mus musculus 
2015-02-18 | E-GEOD-65997 | biostudies-arrayexpress
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