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UnknownImproved analysis of CRISPR fitness screens and reduced off-target effects with the BAGEL2 gene essentiality classifier.
Not available
S-EPMC7789424 | biostudies-literature
UnknownIdentifying chemogenetic interactions from CRISPR screens with drugZ.
Not available
S-EPMC6706933 | biostudies-literature
UnknownOptimal construction of a functional interaction network from pooled library CRISPR fitness screens.
Not available
S-EPMC9707256 | biostudies-literature
UnknownMultiplex enCas12a screens detect functional buffering among paralogs otherwise masked in monogenic Cas9 knockout screens.
Not available
S-EPMC7558751 | biostudies-literature
UnknownA network of human functional gene interactions from knockout fitness screens in cancer cells.
Not available
S-EPMC6464042 | biostudies-literature
UnknownDynamic rewiring of biological activity across genotype and lineage revealed by context-dependent functional interactions.
Not available
S-EPMC9241233 | biostudies-literature
UnknownAR-negative prostate cancer is vulnerable to loss of JMJD1C demethylase.
Not available
S-EPMC8433584 | biostudies-literature
UnknownDiscovery of putative tumor suppressors from CRISPR screens reveals rewired lipid metabolism in acute myeloid leukemia cells.
Not available
S-EPMC8586352 | biostudies-literature
GenomicsApplication of Microdroplet PCR for Large-Scale Targeted Bisulfite Sequencing
Cytosine methylation of DNA CpG dinucleotides in gene promoters is an epigenetic modification that regulates gene transcription. While many methods exist to interrogate methylation states, no current methods offer large-scale, targeted, single CpG resolution. We report an approach combining bisulf...
ORGANISM(S): Homo sapiens 
2011-06-25 | E-GEOD-30179 | biostudies-arrayexpress
TranscriptomicsHigh-Resolution CRISPR Screens Reveal Fitness Genes and Genotype-Specific Cancer Liabilities
The ability to perturb genes in human cells is crucial for elucidating gene function and holds great potential for finding therapeutic targets for diseases such as cancer. To extend the catalog of human core and context- dependent fitness genes, we have developed a high-complexity second-generation ...
ORGANISM(S): Homo sapiens 
2015-11-25 | E-GEOD-75189 | biostudies-arrayexpress
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