In a fluorescence polarization screen for MYC-MAX interaction, we have identified a novel small molecule inhibitor of MYC, KJ-Pyr-9, from a Kröhnke pyridine library. The Kd of KJ-Pyr-9 for MYC in vitro is 6.5 ± 1.0 nM as determined by backscattering interferometry; KJ-Pyr-9 also interferes with MYC-...
Data from ProteomeXchange, PXD ID: PXD001364. Experiment: AggregatesSILAC_DAF16_D01, file: 20110921_Velos3_DiWa_SA_Celegans_AggregatesSILAC_DAF16_D01-3.mzml. Published as part of Cell. 2015 May 7;161(4):919-932 . From the Abstract: {{i}} ... Here, we profiled more than 5, 000 proteins along the lif...
Ecumicin and Cyclomarin A (CymA) are known antimicrobial compounds that target the NTD of ClpC1. In proteomics analysis of compound treated M. smegmatis, two novel protein, ClpC2 and ClpC3, have been identified as strong interactors of those compounds in addition to ClpC1. In this study we used PRM ...
