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TranscriptomicsHeLa cell response to overexpression of wild type and mutated forms of the P19 splice variant of c-H-ras
The c-H-ras proto-oncogene undergoes alternative splicing of the exon termed IDX giving rise to a novel protein of the Ras family, p19 (H-RasIDX). The experiment tests the effect on the transcriptome of overexpressing the wild type and W164A mutated forms of p19. Keywords: genetic modification Thre...
ORGANISM(S): Homo sapiens 
2009-12-29 | E-GEOD-12059 | biostudies-arrayexpress
TranscriptomicsMicroRNA profiling of human HeLa cells overexpressing p19 H-Ras
MicroRNA miRNA expression profiles for human HeLa cells (Cervical cancer), overexpressing p19 H-Ras, were examined to investigate the miRNA regulation by p19 H-Ras. miRNA microarray analysis identified statistical unique profiles, which could discriminate miRNAs regulated by p19 H-Ras and not regul...
ORGANISM(S): Homo sapiens 
2008-12-12 | E-TABM-494 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse macrophaes and mast cells from Pac1+/+ versus Pac1-/- animals
This SuperSeries is composed of the following subset Series:; GSE3993: Pac1+/+ versus Pac1-/- TG-macrophages_LPS 6h; GSE3994: Pac1+/+ versus Pac1-/- BMMCs_IgE-DNP 2 h Experiment Overall Design: Refer to individual Series
ORGANISM(S): Mus musculus 
2008-06-12 | E-GEOD-4014 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of rat resistance artery in 2 models of hypertension
We investigated morphometric structure and gene expression by microarray analysis in a small diameter artery, branch of the saphenous artery (a resistance artery), in representative models of renin-angiotensin system (RAS)-dependent and glucocorticoid hypertension, using the spontaneously hypertensi...
ORGANISM(S): Rattus norvegicus 
2008-06-15 | E-GEOD-8051 | biostudies-arrayexpress
TranscriptomicsmRNA profiling during infection with H1N1 influenza A virus (A/Mexico/InDRE4487/H1N1/2009)
MicroRNAs (miRNAs) repress the expression levels of genes by binding to mRNA transcripts, acting as master regulators of cellular processes. Differential expression of miRNAs has been linked to viral-associated diseases involving members of the hepacivirus, herpesvirus, and retrovirus families. In c...
ORGANISM(S): Homo sapiens 
2012-04-09 | E-GEOD-36553 | biostudies-arrayexpress
TranscriptomicsRNA-seq analysis of differential gene expression in muscle from Holstein Friesian bulls undergoing diet restriction and compensatory growth
The objective of this study was to examine changes in muscle gene expression of growing bulls during a period of dietary energy restriction followed by a period of subsequent realimentation and compensatory growth. Purebred Holstein Friesian bulls (n=20) were assigned to one of two feeding treatment...
ORGANISM(S): Bos taurus 
2015-09-04 | E-GEOD-64289 | biostudies-arrayexpress
TranscriptomicsMiRNA profiling during infection with H1N1 influenza A virus (A/Mexico/InDRE4487/H1N1/2009)
MicroRNAs (miRNAs) repress the expression levels of genes by binding to mRNA transcripts, acting as master regulators of cellular processes. Differential expression of miRNAs has been linked to viral-associated diseases involving members of the hepacivirus, herpesvirus, and retrovirus families. In c...
ORGANISM(S): Homo sapiens 
2012-04-09 | E-GEOD-36461 | biostudies-arrayexpress
TranscriptomicsMiRNA profiling during infection with H7N7 influenza A virus (A/Ck/Germany/R28/H7N7/2003)
MicroRNAs (miRNAs) repress the expression levels of genes by binding to mRNA transcripts, acting as master regulators of cellular processes. Differential expression of miRNAs has been linked to viral-associated diseases involving members of the hepacivirus, herpesvirus, and retrovirus families. In c...
ORGANISM(S): Homo sapiens 
2012-04-09 | E-GEOD-36462 | biostudies-arrayexpress
ProteomicsLC7 Proteomic Analysis of Matched Control and NSCLC Lung Adenocarcinoma Tissue.
Non-small cell lung adenocarcinoma is the most frequently diagnosed lung cancer type and remains the leading cause of cancer mortality for men and women in the United States. Management of lung cancer is hindered by high false-positive rates due to the inability to resolve benign versus malignant tu...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-31 | MSV000080825 | MassIVE
TranscriptomicsFunctional Characterization of Fission Yeast Transcription Factors by Overexpression Analysis
In Schizosaccharomyces pombe, over 90% of transcription factor genes are nonessential. Moreover, the majority do not exhibit significant growth defects under optimal conditions when deleted, complicating their functional characterization and target gene identification. Here, we systematically overex...
ORGANISM(S): Schizosaccharomyces pombe 
2013-05-11 | E-GEOD-46811 | biostudies-arrayexpress
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