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MetabolomicsFecal microbiota transplantation plus anti-PD-1 immunotherapy in advanced melanoma: a phase I trial

Fecal microbiota transplantation (FMT) represents a potential strategy to overcome resistance to immune checkpoint inhibitors in patients with refractory melanoma; however, the role of FMT in first-line treatment settings has not been evaluated. We conducted a multicenter phase I trial combining ...

2025-02-27 | MTBLS711 | MetaboLights
TranscriptomicsDiscovery of novel imprinted genes by transcriptional analysis of parthenogenetic embryonic stem cells
Parthenogenetic embryonic stem cells (PESCs) may have future utility in cell replacement therapies. We examined genome-wide mRNA expression profiles of monkey PESCs relative to ESCs derived from fertilized embryos. Several known paternally-imprinted genes were in the highly down-regulated group in P...
ORGANISM(S): Macaca mulatta 
2010-07-07 | E-GEOD-17964 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human platelets from patients with essential thrombocythemia
Human blood platelets have important, regulatory functions in diverse hemostatic and pathological disorders, including vascular remodeling, inflammation, and wound repair. Microarray analysis was used to study the molecular basis of essential thrombocythemia, a myeloproliferative disorder with quant...
ORGANISM(S): Homo sapiens 
2007-08-31 | E-GEOD-2006 | biostudies-arrayexpress
TranscriptomicsSolar simulated ultraviolet radiation induces histone 3 methylation changes in the gene promoters of matrix metalloproteinases 1 and 3 in primary human dermal fibroblasts [II]
Skin damage from solar ultraviolet radiation (UVR) accumulates in the dermal extracellular matrix (ECM) and contributes to photoaging. Following UVR exposure, matrix metalloproteinases (MMPs) are secreted by dermal fibroblasts to repair and remodel the ECM. Molecular signaling pathways delineating t...
ORGANISM(S): Homo sapiens 
2014-08-27 | E-GEOD-60795 | biostudies-arrayexpress
TranscriptomicsRas Affects Filamentous Growth in Saccharomyces cerevisiae Solely Through Regulation of Protein Kinase A
To assess the relative contributions of the PKA and MAPK pathways in Ras stimulation of filamentation, we examined the change in transcriptional profile following activation of Ras in strains in which one of these two pathways has been severed. These arrays contain the experiments involving WT strai...
ORGANISM(S): Saccharomyces cerevisiae 
2007-08-18 | E-GEOD-8805 | biostudies-arrayexpress
TranscriptomicsPAX3-FOXO1 suppresses cellular senescence through RASSF4-mediated restraint of the mammalian Hippo/MST1 pathway
Alveolar rhabdomyosarcoma (aRMS) is an aggressive sarcoma of skeletal muscle characterized by expression of the PAX3-FOXO1 fusion gene. Despite its discovery over almost 20 years ago, PAX3-FOXO1 remains an enigmatic tumor driver. Previously, we reported that PAX3-FOXO1 supports aRMS initiation by en...
ORGANISM(S): Homo sapiens 
2014-05-15 | E-GEOD-40543 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of rat mast cells from diabetic prone and diabetic resistant strains
Abstract; Human type 1 diabetes mellitus (T1DM) arises through autoimmune destruction of pancreatic β cells and is modeled in many respects by the lymphopenic and spontaneously diabetic BioBreeding (BB) DRlyp/lyp rat. Previously, pre-onset expression profiling of whole DRlyp/lyp pancreatic lymph...
ORGANISM(S): Rattus norvegicus 
2008-06-13 | E-GEOD-4990 | biostudies-arrayexpress
TranscriptomicsPbx and Prdm1a transcription factors differentially regulate subsets of the fast skeletal muscle program in zebrafish
The basic helix-loop-helix factor Myod initiates skeletal muscle differentiation by directly and sequentially activating sets of muscle differentiation genes, including those encoding muscle contractile proteins. We hypothesize that Pbx homeodomain proteins direct Myod to a subset of its transcripti...
ORGANISM(S): Danio rerio 
2013-03-28 | E-GEOD-45532 | biostudies-arrayexpress
TranscriptomicsExpression profiling of skeletal muscle in beef cattle treated with steroidal growth promoters
In the present study, a oligonucleotide microarray platform is used to compare expression profiles of beef cattle muscle in animals treated with either Dexamethazone (Dex) or Dexamethazone plus 17?-estradiol (Estr) administered at sub-therapeutic dosage, against untreated controls. Seventeen male be...
ORGANISM(S): Bos taurus 
2009-07-07 | E-GEOD-12179 | biostudies-arrayexpress
TranscriptomicsSox9 duplications cause Sry-negative XX sex-reversal in dogs
Sexual development in mammals is based on a complicated and delicate network of genes and hormones that have to collaborate in a precise manner. The dark side of this pathway is represented by pathological conditions, wherein sexual development does not occur properly either in the XX and the XY bac...
ORGANISM(S): Canis lupus familiaris 
2014-08-05 | E-GEOD-57137 | biostudies-arrayexpress
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