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TranscriptomicsTranscription profiling of human MCF7 cells treated with ErbB receptor ligands EGF and heregulin at multiple doses and sampled at multiple time points reveals signal transduction pathways devotedly convey quantitative properties of the dose-dependent activation of ErbB receptor to early transcription
ErbB receptor ligands, epidermal growth factor (EGF) and heregulin (HRG), induce dose-dependent transient and sustained intracellular signaling, proliferation and differentiation of MCF-7 breast cancer cells, respectively. In an effort to delineate the ligand-specific cell determination mechanism, w...
ORGANISM(S): Homo sapiens 
2007-11-01 | E-GEOD-6462 | biostudies-arrayexpress
ModelsHatakeyama2003_MAPK
Figure4 and Figure5 can be simulated by Copasi. Figure4 can be simulated in MathSBML as well. There are some typos in the paper:K29=234, is it should k_29; Table2, reaction17, is there are "slash" missing in between the rate equation; reaction 33,"Akt-PI-PP" in the last term of denominator instead o...
2024-09-02 | BIOMD0000000146 | BioModels
ModelsNakakuki2010_CellFateDecision_Core
This model describes the activation of immediate early genes such as cFos after EGF or heregulin (HRG) stimulation of the MAPK pathway. Phosphorylated cFos is a key transcription factor triggering downstream cascades of cell fate determination. The model can explain how the switch-like response of p...
2024-09-02 | BIOMD0000000251 | BioModels
TranscriptomicsTranscription profiling of human H1299 non-small-cell lung cancer cells (parental H1299, H1299 cells which overexpress wild-type: EGFR-WT and mutant EGFR: L858R) after EGF and Iressa stimulation
Controlled activation of epidermal growth factor receptor (EGFR) is systematically guaranteed at the molecular level, however aberrant activation of EGFR is frequently found in cancer. Transcription induced by EGFR activation often involves coordinated expression of genes that positively and negativ...
ORGANISM(S): Homo sapiens 
2009-08-09 | E-GEOD-11729 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human MCF7 breast cancer cells MCF-7 two hours post incubation with heregulin (HRG)) vs. controls to detect HRG regulated genes
Heregulin beta-1 (HRG) is an extracellular ligand that activates mitogen-activated protein kinase (MAPK) and phosphatidylinositol-3-OH kinase (PI3K)/Akt signaling pathways through ErbB receptors. MAPK and Akt have been shown to phosphorylate the estrogen receptor (ER) at Ser-118 and Ser-167, respect...
ORGANISM(S): Homo sapiens 
2008-04-08 | E-GEOD-8471 | biostudies-arrayexpress
ModelsBirtwistle2007_ErbB_Signalling
This model originates from BioModels Database: A Database of Annotated Published Models. It is copyright (c) 2005-2009 The BioModels Team.For more information see the terms of use.To cite BioModels Database, please use Le Novère N., Bornstein B., Broicher A., Courtot M., Donizelli M., Dharuri H., L...
2024-09-02 | BIOMD0000000175 | BioModels
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