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ProteomicsHAX1-interactome in breast cancer cell line (MCF7)
The MCF7 cell line represents a typical epithelial cell line and corresponds to luminal A breast cancer (estrogen-responsive). Overexpression of HAX1 was demonstrated in MCF7 cell line as well as in breast cancer samples, suggesting a role of HAX1 in breast cancer progression. HAX1 is a 32-kDa prote...
ORGANISM(S): Homo sapiens (Human) 
2019-11-14 | PXD007888 | Pride
Mcf7 Hax1 Interactome 
ProteomicsHAX1-interactome in cervical cancer cell line (HeLa)
HAX1 is a 32-kDa protein of unknown structure, involved in the regulation of apoptosis, cell migration and calcium homeostasis. It was also shown to bind mRNA. Scarcity of structural elements and the presence of a disordered region, inferred from HAX1 sequence, suggests that HAX1 is intrinsically di...
ORGANISM(S): Homo sapiens (Human) 
2020-11-11 | PXD007887 | Pride
Hax1 Hela Interactome 
ProteomicsQuantitative mass spectrometry of HAX1 WT and HAX1 KO promyelocytic cells reveal differences in amino acid synthesis and lipid metabolism
part of a project: Granulocyte differentiation arrest in HAX1-deficient cells demonstrated in a new in vitro model of Kostmann disease, is caused by ineffective lipid droplet autophagy and fatty acids uptake. Molecular and metabolic mechanisms underlying congenital neutropenia in patients with HAX1 ...
ORGANISM(S): Homo sapiens (Human) 
2026-04-22 | PXD064511 | Pride
Hax1 Lipid metabolism Lipid droplet autophagy Kostmann disease Neutrophil differentiation 
ProteomicsHAX1-interactome in Colorectal Cancer cell line (HCT116)
We performed immune-affinity purification and resolved the binding partners utilizing mass spectrometry to elucidate the molecular mechanism of HAX1-mediated CRC progression. HCT116 cells transfected with empty vector or Flag-HAX1 and then immunoprecipitated using anti-Flag M2 beads. The purified HA...
ORGANISM(S): Homo Sapiens 
2024-01-11 | PXD048485 |
GenomicsIdentification of genes differentially expressed in HAX1-deficient HL-60 cells
Identification of genes differentially expressed in HAX1-deficient HL-60 cells
PRJNA783875 | ENA
GenomicsRNA immunoprecipitation and next generation sequencing (RIP-seq) specific for HAX1 protein
RNA immunoprecipitation and next generation sequencing (RIP-seq) specific for HAX1 protein
PRJNA783884 | ENA
ProteomicsHAX1 controls mitochondrial proteostasis
The relevance of mitochondrial proteostasis for the differentiation and function of hematopoietic and immune cells is unknown. Dissecting the HCLS1-associated protein X-1 (HAX1) –related protein network, we define a functional CLPB-HAX1-PRKD2-HSP27 axis with critical importance for the differentiati...
ORGANISM(S): Homo sapiens (Human) 
2022-05-19 | PXD023790 | Pride
Inborn errors of immunity Severe congenital neutropenia Protein quality control Hematopoiesis 
TranscriptomicsIdentification of genes differentially expressed in HAX1-deficient HL-60 cells
RNA sequencing was performed to compare levels of intracellular transcripts in HL-60 WT and HL-60 HAX1 KO cells. Experiment was performed to check influence of HAX1 protein on cellular transcriptome (in HL-60 cell line)
ORGANISM(S): Homo sapiens 
2022-09-21 | GSE189609 | GEO
TranscriptomicsRNA immunoprecipitation and next generation sequencing (RIP-seq) specific for HAX1 protein
RNA immunoprecipitation was performed to characterize RNA interactome specific to endogenous HAX1 protein
ORGANISM(S): Homo sapiens 
2022-09-21 | GSE189611 | GEO
UnknownHax1 regulate focal adhesion dynamics through IQGAP1.
Not available
S-EPMC10364419 | biostudies-literature
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