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TranscriptomicsWhole genome expression array profiling highlights differences in mucosal defense genes in Barrett's esophagus and esophageal adenocarcinoma.
Esophageal adenocarcinoma (EAC) has become a major concern in Western countries due to rapid rises in incidence coupled with very poor survival rates. One of the key risk factors for the development of this cancer is the presence of Barrett’s esophagus (BE), which is believed to form in response to ...
ORGANISM(S): Homo sapiens 
2011-08-16 | E-GEOD-28302 | biostudies-arrayexpress
TranscriptomicsHuman lung adenocarcinoma DNA copy number profiling
Lung adenocarcinoma’s genomic alterations exhibit vast variation. Lung adenocarcinoma also has previously described intrinsic gene expression subtypes (Hayes et al. 2006, PMID: 17075127). This study’s aim was to detect and validate subtype-specific alterations. A portion of these specimens were a...
ORGANISM(S): Homo sapiens 
2012-05-16 | E-GEOD-36363 | biostudies-arrayexpress
TranscriptomicsmiRNA profiling of Melanoma Cell lines and Normal Melanocytes
To identify microRNAs potentially involved in melanomagenesis we compared microRNA transcription profiles between melanoma cell lines and cultured melanocytes. miRNA microarrays were manufactured by Agilent Technologies (Santa Clara, CA), and contain 20-40 features targeting each of 470 human miRNAs...
ORGANISM(S): Homo sapiens 
2011-10-16 | E-GEOD-25653 | biostudies-arrayexpress
TranscriptomicsExpression Profiles of Monozygotic Twin
The expression level for 15 887 transcripts in lymphoblastoid cell lines from 19 monozygotic twin pairs (10 male, 9 female) were analysed for the effects of genotype and sex. On an average, the effect of twin pairs explained 31% of the variance in normalized gene expression levels, consistent with p...
ORGANISM(S): Homo sapiens 
2008-03-30 | E-GEOD-7624 | biostudies-arrayexpress
TranscriptomicsHuman lung adenocarcinoma DNA methylation profiling by MSNP
Lung adenocarcinoma’s genomic alterations exhibit vast variation. Lung adenocarcinoma also has previously described intrinsic gene expression subtypes (Hayes et al. 2006, PMID: 17075127). This study detect global methylation differences among gene expression subtypes. These specimens were also assay...
ORGANISM(S): Homo sapiens 
2012-05-16 | E-GEOD-36438 | biostudies-arrayexpress
TranscriptomicsADAM-28: A potential oncogene involved in asbestos-related lung adenocarcinomas
To identify gene expression biomarkers associated with asbestos-related lung adenocarcinoma, we analyzed primary tumour gene expression for a total of 36 primary lung adenocarcinomas on 22,323 element microarrays, comparing 12 patients with lung asbestos body counts above levels associated with urba...
ORGANISM(S): Homo sapiens 
2010-05-28 | E-GEOD-20875 | biostudies-arrayexpress
GenomicsGenomic catastrophes frequently arise in esophageal adenocarcinoma and drive tumorigenesis.
Oesophageal adenocarcinoma (EAC) incidence is rapidly increasing in Western countries. A better understanding of EAC underpins efforts to improve early detection and treatment outcomes. While large EAC exome sequencing efforts to date have found recurrent loss-of-function mutations, oncogenic drivin...
EGAS00001000750 | EGA
TranscriptomicsmicroRNA Expression in HCC Tissues and Cells
Cell Lines, Cultures and HCC Tumor Tissues.
Malignant and non-malignant hepatocyte cell lines were obtained from the American Type Culture Collection (Manassas, VA) and cultured as recommended by the supplier. Total RNA from three paires of normal human liver tissue and from hepatocellular car...
ORGANISM(S): Homo sapiens 
2011-08-03 | E-MEXP-1125 | biostudies-arrayexpress
TranscriptomicsPredominance of MAPK reactivation in early resistance to debrafenib/trametinib combination therapy of BRAF mutant metastatic melanoma.
One third of BRAF-mutant metastatic melanoma patients treated with combined BRAF and MEK inhibition progress within six months. Treatment options for these patients remain limited. Here we analyse twenty BRAFV600 mutant melanoma metastases derived from 10 patients treated with the combination of deb...
ORGANISM(S): Homo sapiens 
2014-12-03 | E-GEOD-61992 | biostudies-arrayexpress
UnknownHLA-DP on Epithelial Cells Enables Tissue Damage by NKp44<sup>+</sup> Natural Killer Cells in Ulcerative Colitis.
Not available
S-EPMC10529779 | biostudies-literature
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