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This study investigates transcriptomic changes in human coronary artery endothelial cells (HCAEC) following siRNA-mediated gene silencing. Cells were transfected with either scrambled control siRNA or siRNA targeting VKORC1 or VKORC1L1. Total RNA was extracted and subjected to bulk RNA sequencing to...
ORGANISM(S): Homo sapiens 
RNA-Seq of HCAEC treated with siRNA against scrambled or VKORC1 or VKORC1L1
RNA-seq of PRDM15 overexpression in HCAEC
This is an investigation of whole genome gene expression level in human coronary endothelial cells (HCAEC) and human pulmonary endothelial cells (HPAEC) stimulated by FK565 or LipidA. We show that parenteral administration of a pure synthetic Nod1 ligand, FK565, induces site-specific vascular inflam...
ORGANISM(S): Homo sapiens 
Early onset sepsis due to Group B streptococcus (GBS) leads to neonatal morbidity, increased mortality and long term neurological deficencies. Interaction between septicemic GBS and confluent monlayers of human coronary artery endothelial cells (HCAEC) was analyzed by a genome wide expression profil...
ORGANISM(S): Homo sapiens 
Calciprotein particles (CPPs) are indispensable scavengers of excessive Ca2+ and PO43- ions in the blood, being internalized and recycled by liver and spleen macrophages, monocytes, and endothelial cells (ECs). Despite the fact, that CPPs are associated with many cardiovascular diseases and are know...
ORGANISM(S): Homo sapiens (Human) 
2023-12-31 | PXD047581 | Pride
Currently, it is well established that human endothelial cells (ECs) are characterised by a significant heterogeneity between distinct blood vessels, e.g., arteries, veins, capillaries, and lymphatic vessels. Further, even ECs belonging to the same lineage but grown under different flow patterns (e....
ORGANISM(S): Homo sapiens (Human) 
2023-10-17 | PXD037861 | Pride
Myocyte enhancer factor 2A (MEF2A) is a crucial transcritional activator which plays diverse roles in the control of cell growth, survival, apoptosis and inflammation etc. To expore the gene expression signature of human coronary artery endothelial cells (HCAEC) in reponse to inhibition of MEF2A, we...
ORGANISM(S): Homo sapiens 
2019-01-01 | GSE114114 | GEO
Calciprotein particles (CPPs), assembled as a result of molecular interactions between fetuin-A and nascent calcium phosphate clusters, are indispensable scavengers of excessive Ca2+ and PO43– ions, thus representing an elegant mechanism which regulates mineral homeostasis. Generation of CPPs repres...
ORGANISM(S): Homo sapiens (Human) 
2024-10-24 | PXD055909 | Pride
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