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ProteomicsNuclear Location Bias of HCAR1 Drives Cancer Malignancy through Numerous Routes
The involvement of G-Protein-Coupled Receptors’ (GPCR) location bias in diverse cellular functions and their misregulation in pathology is an underexplored territory. HCAR1, a GPCR for lactate is linked to cancer progression, mainly due to Warburg effect, but its mechanism of action remains elusive....
ORGANISM(S): Homo sapiens (Human) 
2025-01-22 | PXD035882 | Pride
Signaling Lactate Hcar1 Location bias Cancer Warburg effect Nucleus Gpcr 
GenomicsHCAR1 nuclear transportation is critical for cell function
HCAR1 nuclear transportation is critical for cell function
PRJNA1064959 | ENA
GenomicsHCAR1 nuclear transportation is critical for cell function
Membrane receptor nuclear translocation play some novel role in cancer pathology. In the current studies, we demonstrate HCAR1 distributes in cancer cell nucleus in Lung cancer; Lactate promote HCAR1 nuclear translocation. Proteomics analysis found there are a set of nuclear proteins binds with HCAR...
ORGANISM(S): Homo sapiens 
2024-02-20 | GSE253282 | GEO
GenomicsNuclear Location Bias of HCAR1 Drives Cancer Malignancy through Numerous Routes [RNA-seq]
Nuclear Location Bias of HCAR1 Drives Cancer Malignancy through Numerous Routes [RNA-seq]
PRJNA865755 | ENA
GenomicsNuclear Location Bias of HCAR1 Drives Cancer Malignancy through Numerous Routes [ChIP-seq]
Nuclear Location Bias of HCAR1 Drives Cancer Malignancy through Numerous Routes [ChIP-seq]
PRJNA865741 | ENA
TranscriptomicsNuclear Location Bias of HCAR1 Drives Cancer Malignancy through Numerous Routes [RNA-seq]
The involvement of G-Protein-Coupled Receptors’ (GPCR) location bias in diverse cellular functions and their misregulation in pathology is an underexplored territory. HCAR1, a GPCR for lactate is linked to cancer progression, mainly due to Warburg effect, but its mechanism of action remains elusive....
ORGANISM(S): Homo sapiens 
2023-11-15 | GSE210469 | GEO
GenomicsNuclear Location Bias of HCAR1 Drives Cancer Malignancy through Numerous Routes [ChIP-seq]
The involvement of G-Protein-Coupled Receptors’ (GPCR) location bias in diverse cellular functions and their misregulation in pathology is an underexplored territory. HCAR1, a GPCR for lactate is linked to cancer progression, mainly due to Warburg effect, but its mechanism of action remains elusive....
ORGANISM(S): Homo sapiens 
2023-11-15 | GSE210455 | GEO
UnknownThe lactate receptor HCAR1: A key modulator of epileptic seizure activity.
Not available
S-EPMC11035371 | biostudies-literature
UnknownLack of HCAR1, the lactate GPCR, signaling promotes autistic-like behavior.
Not available
S-EPMC10634184 | biostudies-literature
UnknownExercise induces cerebral VEGF and angiogenesis via the lactate receptor HCAR1.
Not available
S-EPMC5457513 | biostudies-literature
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