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TranscriptomicsIdentification of Wnt target genes associated with malignant phenotypes in CTNNB1-mutated NSCLC
Microarray analysis comparing the expression profiles of siRNA-mediated CTNNB1-silenced and CTNNB1-retained HCC15 cells harboring a homozygous CTNNB1 S45F mutation revealed that besides several known Wnt genes, LGR6 was significantly downregulated by CTNNB1 knockdown in HCC15 cells.
ORGANISM(S): Homo sapiens 
2022-09-01 | GSE183178 | GEO
GenomicsIdentification of Wnt target genes associated with malignant phenotypes in CTNNB1-mutated NSCLC
Identification of Wnt target genes associated with malignant phenotypes in CTNNB1-mutated NSCLC
PRJNA759564 | ENA
UnknownAuthor Correction: Inflammation-induced IgA+ cells dismantle anti-liver cancer immunity.
Not available
S-EPMC7871211 | biostudies-literature
UnknownThe oncogenic role of LGR6 overexpression induced by aberrant Wnt/β-catenin signaling in lung cancer.
Not available
S-EPMC10788478 | biostudies-literature
UnknownSelective inhibition of TGF-β-induced epithelial-mesenchymal transition overcomes chemotherapy resistance in high-risk lung squamous cell carcinoma.
Not available
S-EPMC11787392 | biostudies-literature
ProteomicsComparative proteomics reveals a diagnostic signature for pulmonary head-and-neck cancer metastasis.
This study represents a proteomic resource for HNSCC and SQCLC with quantitative protein expression data for 7800 proteins and provides a proteomic diagnostic signature for classification for undetermined secondary lung tumors in HNSCC patients. By quantitative mass-spectrometry-based proteomics, we...
ORGANISM(S): Homo sapiens (Human) 
2018-08-06 | PXD007705 | Pride
Head and neck cancer Human tissue proteomics Lung cancer Squamous cell carcinoma Diagnostic biomarker Metastasis 
ProteomicsPDGFRalpha/beta heterodimer activation negatively affects downstream ERK1/2 signaling and cellular proliferation
The platelet-derived growth factor receptor (PDGFR) family of receptor tyrosine kinases consists of two receptors, PDGFRalpha and PDGFRbeta, that homodimerize and heterodimerize upon ligand binding. Here, we tested the hypothesis that differential internalization and trafficking dynamics of the vari...
ORGANISM(S): Homo sapiens (Human) 
2025-04-25 | PXD048421 | Pride
Global proteomics Silac Pdgfr Hcc15 
GenomicsIdentification of LGR6-associated genes in NSCLC
Identification of LGR6-associated genes in NSCLC
PRJNA902646 | ENA
GenomicsDifferential transcriptional responses to BIRC6 depletion between BIRC6-dependent and -nondependent cells
Differential transcriptional responses to BIRC6 depletion between BIRC6-dependent and -nondependent cells
PRJNA914287 | ENA
TranscriptomicsExpression profile of peripheral blood mononuclear cells obtained from type C cirrhotic patients
Study goal is to disclose features of gene expression profile of peripheral blood mononuclear cells obtained from type C cirrhotic patients with or without hepatocellular carcinomas. Peripheral blood mononuclear cells were obtained from 32 type C cirrhotic patients without hepatocellular carcinoma (...
ORGANISM(S): Homo sapiens 
2010-06-25 | E-GEOD-10459 | biostudies-arrayexpress
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