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TranscriptomicsTranscriptome profiling of human urothelial carcinoma cell lines RT-112, VM-Cub-1, SW1710, UMUC3 and a benign urothelial control HBLAK engineered to stably express HDAC5 against their vector control
Aberrant expression of histone deacetylases (HDACs) and their activity are associated with a broad range of tumor development. However, based on cell or tissue types, class IIA HDACs such as HDAC4 and HDAC5 may facilitate or inhibit cancer progression. The goal of this project is to examine the gene...
ORGANISM(S): Homo sapiens 
2019-11-13 | E-MTAB-8418 | biostudies-arrayexpress
GenomicsHDAC5-ChIP seq data in HDAC5-driven KRASG12D-independent PDAC cells
HDAC5-ChIP seq data in HDAC5-driven KRASG12D-independent PDAC cells
PRJNA531704 | ENA
GenomicsRNAseq data comparing HDAC5 eccaper PDAC cells with HDAC5 knockdown and scramble control
RNAseq data comparing HDAC5 eccaper PDAC cells with HDAC5 knockdown and scramble control
PRJNA627429 | ENA
ProteomicsEpigenetic control of an auxiliary subunit of sodium voltage-gated channels regulates the strength of drug-cue associations and relapse-like cocaine seekingEpigenetic control of an auxiliary subunit of sodium voltage-gated channels regulates the strength of drug-cue associations and relapse-like cocaine seeking
Repeated use of illicit drugs produces long-lasting and prepotent drug-cue associations that increase vulnerability for relapse in individuals with a substance use disorder. Epigenetic factors like histone deacetylase 5 (HDAC5) play a key role in regulating the formation of drug-cue associations, bu...
ORGANISM(S): Homo sapiens (Human) Rattus norvegicus (Rat) 
2025-02-18 | PXD055005 | Pride
Reinstatement behavior Excitability Nucleus accumbens Substance use disorder Epigenetics 
GenomicsHistone modifications regulated by HDAC5 in PDAC cells
Histone modifications regulated by HDAC5 in PDAC cells
PRJNA627431 | ENA
GenomicsHDAC5 regulates arachidonic acid metabolism via cPLA2
HDAC5 regulates arachidonic acid metabolism via cPLA2
PRJNA770975 | ENA
GenomicsHDAC5-ChIP seq data in HDAC5-driven KRASG12D-independent PDAC cells
HDAC5 belongs to Class IIa histone deacetylases and forms corepressor complex with HDAC3 to suppess gene expression. To identify the target genes of HDAC5, we performed ChIP-seq analysis in FLAG-tagged HDAC5 PDAC escaper cells. HDAC5 binding chromatins were pulled down by HDAC5 antibody and FLAG ant...
ORGANISM(S): Mus musculus 
2020-04-27 | GSE129549 | GEO
TranscriptomicsRNAseq data comparing HDAC5 eccaper PDAC cells with HDAC5 knockdown and scramble control
HDAC5 drives PDAC cells to bypass KRAS* dependency. To dissect the molecular mechanisms that regulated by overexpressed HDAC5 in escaper cells, we conducted RNA-seq analysis of HDAC5 escaper PDAC cells knocking down of HDAC5 or scramble shRNA control.
ORGANISM(S): Mus musculus 
2020-04-27 | GSE149127 | GEO
ProteomicsProtein expression profiling of human urothelial carcinoma cell lines RT-112, VM-Cub-1, SW1710, UMUC3 and a benign urothelial control HBLAK engineered to stably express HDAC5 against their vector control
Aberrant expression of histone deacetylases (HDACs) and their activity are associated with a broad range of tumor development. However, based on cell or tissue types, class IIA HDACs such as HDAC4 and HDAC5 may facilitate or inhibit cancer progression. The goal of this project is to examine the over...
ORGANISM(S): Homo sapiens (Human) 
2022-03-14 | PXD014448 | Pride
Cancer Proteomics Urothelial carcinoma Cell lines Hdac 
GenomicsHistone modifications regulated by HDAC5 in PDAC cells
HDAC5 belongs to Class IIa histone deacetylases and forms corepressor complex with HDAC3. To understand the epignetic regulations by HDAC5, we performed ChIP-seq analysis of H3K4me3, H3K27ac and H3K9ac in PDAC cells overexpressing GFP or HDAC5, and in HDAC5 escaper cells with HDAC5 knockdown or scra...
ORGANISM(S): Mus musculus 
2020-04-27 | GSE149125 | GEO
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